NP_001243143.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,059 Da
NCBI Official Full Name
sodium/potassium-transporting ATPase subunit alpha-3 isoform 3
NCBI Official Synonym Full Names
ATPase Na+/K+ transporting subunit alpha 3
NCBI Protein Information
sodium/potassium-transporting ATPase subunit alpha-3
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit alpha-3
UniProt Synonym Protein Names
Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3
UniProt Synonym Gene Names
UniProt Entry Name
AT1A3_HUMAN
NCBI Summary for Atp1a3
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for Atp1a3
ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
Protein type: Transporter, ion channel; Hydrolase; Membrane protein, multi-pass; Endoplasmic reticulum; Transporter; Membrane protein, integral; EC 3.6.3.9
Chromosomal Location of Human Ortholog: 19q13.31
Cellular Component: axon; endoplasmic reticulum; Golgi apparatus; integral to membrane; myelin sheath; nucleus; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex; synapse
Molecular Function: ATP binding; chaperone binding; D1 dopamine receptor binding; heparan sulfate proteoglycan binding; metal ion binding; sodium:potassium-exchanging ATPase activity
Biological Process: adult locomotory behavior; ATP hydrolysis coupled proton transport; cardiac muscle contraction; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; ionotropic glutamate receptor signaling pathway; memory; metabolic process; potassium ion import; response to drug; transmembrane transport; visual learning
Disease: Alternating Hemiplegia Of Childhood 2; Cerebellar Ataxia, Areflexia, Pes Cavus, Optic Atrophy, And Sensorineural Hearing Loss; Dystonia 12
Research Articles on Atp1a3
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Pathways associated with Atp1a3 elisa kit
Diseases associated with Atp1a3 elisa kit
Organs/Tissues associated with Atp1a3 elisa kit
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