AAC60635.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,237 Da
NCBI Official Full Name
Soluble interleukin-6 receptor, partial
NCBI Official Synonym Full Names
interleukin 6 receptor
NCBI Official Synonym Symbols
IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1 [Similar Products]
NCBI Protein Information
interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha
UniProt Protein Name
Interleukin-6 receptor subunit alpha
UniProt Synonym Protein Names
IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126
UniProt Synonym Gene Names
IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80 [Similar Products]
UniProt Entry Name
IL6RA_HUMAN
NCBI Summary for Sil-6R/cd126
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
UniProt Comments for Sil-6R/cd126
IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; extracellular region; interleukin-6 receptor complex
Molecular Function: protein binding; interleukin-6 receptor binding; protein homodimerization activity; enzyme binding; interleukin-6 binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity
Biological Process: negative regulation of collagen biosynthetic process; positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; neutrophil mediated immunity; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; defense response to Gram-negative bacterium; endocrine pancreas development; positive regulation of chemokine production; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; monocyte chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; acute-phase response; negative regulation of interleukin-8 production; hepatic immune response
Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus
Research Articles on Sil-6R/cd126
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Diseases associated with Sil-6R/cd126 elisa kit
Organs/Tissues associated with Sil-6R/cd126 elisa kit
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