AAB35922.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,667 Da
NCBI Official Full Name
stem cell factor, partial
NCBI Official Synonym Full Names
KIT ligand
NCBI Official Synonym Symbols
SF; MGF; SCF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7 [Similar Products]
NCBI Protein Information
kit ligand
UniProt Protein Name
Kit ligand
UniProt Synonym Protein Names
Mast cell growth factor; MGF
UniProt Synonym Gene Names
UniProt Entry Name
SCF_HUMAN
NCBI Summary for SCF
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SCF
SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: cytoplasm; cytoskeleton; extracellular region; extracellular space; integral to membrane; plasma membrane
Molecular Function: cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding
Biological Process: activation of MAPKK activity; axon guidance; cell adhesion; cell proliferation; embryonic hemopoiesis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; germ cell programmed cell death; innate immune response; insulin receptor signaling pathway; male gonad development; MAPKKK cascade; negative regulation of mast cell apoptosis; nerve growth factor receptor signaling pathway; neural crest cell migration; ovarian follicle development; phosphoinositide-mediated signaling; positive regulation of DNA replication; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Disease: Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7
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