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SNCa elisa kit :: Rat Synuclein Alpha ELISA Kit

Scan QR to view Datasheet Catalog #    MBS762671
Typical Standard Curve/Testing Data
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $415 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synuclein Alpha (SNCa), ELISA Kit

★Popular Item★
 Also Known As   

Rat Synuclein Alpha ELISA Kit

 Product Synonym Names    SNCa/NACP/PARK1/PARK4/PD1/SNCA/Lewy body) 4/MGC110988/non A-beta component of AD amyloid/Non-A beta component of AD amyloid/non-A4 component of amyloid/Non-A4 component of amyloid precursor/PARK1/PARK4/synuclein; alpha (non A4 component of amyloid precursor)
 Product Gene Name   

SNCa elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS762671 COA    COA PDF
 OMIM    127750
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of SNCa. No significant cross-reactivity or interference between SNCa and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates and other biological fluids
 Assay Type    Quantitative Sandwich
 Detection Range    15.625-1000pg/ml
 Sensitivity    <9.375pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level SNCa were tested 20 times on one plate, respectively. Intra-Assay: CV<8%
 Inter-assay Precision    Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level SNCa were tested on 3 different plates, 8 replicates in each plate. CV (%) = SD/meanX100. Inter-Assay: CV<10%
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 Preparation and Storage    Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SNCa elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SNCa purchase    MBS762671 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Synuclein Alpha (SNCa) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.625-1000pg/ml in biological research samples containing SNCa, with an estimated sensitivity of <9.375pg/ml. The ELISA analytical biochemical technique of the MBS762671 kit is based on SNCa antibody-SNCa antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SNCa antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SNCa. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates and other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for SNCa elisa kit

   Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti- SNCa antibody was pre-coated onto 96-well plates. And the biotin conjugated anti- SNCa antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and washed with wash buffer. HRPStreptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the SNCa amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration of SNCa can be calculated.
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 Typical Standard Curve/Testing Data of SNCa elisa kit    SNCa elisa kit Typical Standard Curve/Testing Data image
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Sample Manual Insert of MBS762671. Click to request current manual
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NCBI/Uniprot data below describe general gene information for SNCa. It may not necessarily be applicable to this product.
 NCBI GI #    16356657
 NCBI GeneID    6622
 NCBI Accession #    AAL15443.1 [Other Products]
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 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    13,109 Da
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 NCBI Official Full Name    synuclein alpha
 NCBI Official Synonym Full Names    synuclein alpha
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCa    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
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 UniProt Comments for SNCa    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: actin cytoskeleton; axon; cell cortex; cell junction; cytoplasm; cytosol; extracellular region; extracellular space; fibril; Golgi apparatus; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; ribosome; rough endoplasmic reticulum; synaptic vesicle; terminal button

Molecular Function: alpha-tubulin binding; beta-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; dynein binding; fatty acid binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; microtubule binding; oxidoreductase activity; phospholipase binding; phospholipid binding; phosphoprotein binding; protein binding; protein domain specific binding; protein N-terminus binding; tau protein binding; zinc ion binding

Biological Process: adult locomotory behavior; aging; behavioral response to cocaine; calcium ion homeostasis; caspase activation; cellular protein metabolic process; dopamine biosynthetic process; dopamine uptake; fatty acid metabolic process; fibril organization and biogenesis; microglial cell activation; mitochondrial membrane organization and biogenesis; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine metabolic process; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of neuron apoptosis; negative regulation of norepinephrine uptake; negative regulation of protein amino acid phosphorylation; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; neutral lipid metabolic process; organelle ATP synthesis coupled electron transport; phospholipid metabolic process; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of excitatory postsynaptic membrane potential; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; response to drug; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synapse organization and biogenesis; synaptic vesicle endocytosis

Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant
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 Research Articles on SNCa    1. This study demonstrated that Depressive-like phenotype induced by AAV-mediated overexpression of human alpha-synuclein in midbrain dopaminergic neurons.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNCa elisa kitPathways associated with SNCa elisa kit
 Reference Product  PubMed Publications
 PARK2 elisa kit  >1024 publications with SNCa and PARK2
 MAPT elisa kit  >93 publications with SNCa and MAPT
 PARK7 elisa kit  >57 publications with SNCa and PARK7
 SNCAIP elisa kit  >33 publications with SNCa and SNCAIP
 SLC6A3 elisa kit  >27 publications with SNCa and SLC6A3
 APP elisa kit  >19 publications with SNCa and APP
 FYN elisa kit  >2 publications with SNCa and FYN
 UBC elisa kit  >1 publications with SNCa and UBC
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloid Fiber Formation Pathway antibodies  Amyloid Fiber Formation Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with SNCa elisa kitOrgans/Tissues associated with SNCa elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1264 publications with SNCa and Nervous System Diseases
 Brain Diseases Antibodies  >1239 publications with SNCa and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1221 publications with SNCa and Neurodegenerative Diseases
 Movement Disorders Antibodies  >1098 publications with SNCa and Movement Disorders
 Parkinsonian Disorders Antibodies  >1014 publications with SNCa and Parkinsonian Disorders
 Parkinson Disease Antibodies  >958 publications with SNCa and Parkinson Disease
 Lewy Body Disease Antibodies  >300 publications with SNCa and Lewy Body Disease
 Nerve Degeneration Antibodies  >174 publications with SNCa and Nerve Degeneration
 Disease Models, Animal Antibodies  >171 publications with SNCa and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >58 publications with SNCa and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1017 publications with SNCa and Nerve
 Brain Antibodies  >882 publications with SNCa and Brain
 Blood Antibodies  >93 publications with SNCa and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCa and Embryonic Tissue
 Kidney Antibodies  >21 publications with SNCa and Kidney
 Heart Antibodies  >13 publications with SNCa and Heart
 Eye Antibodies  >12 publications with SNCa and Eye
 Liver Antibodies  >11 publications with SNCa and Liver
 Vascular Antibodies  >10 publications with SNCa and Vascular
 Skin Antibodies  >8 publications with SNCa and Skin
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