NP_113726.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
26,196 Da
NCBI Official Full Name
T-cell surface glycoprotein CD8 alpha chain
NCBI Official Synonym Full Names
CD8a molecule
NCBI Protein Information
T-cell surface glycoprotein CD8 alpha chain
UniProt Protein Name
T-cell surface glycoprotein CD8 alpha chain
UniProt Synonym Protein Names
CD8 antigen 32 kDa chain; OX-8 membrane antigen; CD_antigen: CD8a
UniProt Entry Name
CD8A_RAT
NCBI Summary for Cd8a
increased expression on mast cells is induced by nitric oxide; may play a role in inflammatory response [RGD, Feb 2006]
UniProt Comments for Cd8a
CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Cellular Component: cell surface; external side of plasma membrane; integral to membrane
Molecular Function: protein homodimerization activity; protein kinase binding
Biological Process: cell surface receptor linked signal transduction; cytotoxic T cell differentiation; defense response to virus; inflammatory response; positive regulation of calcium-mediated signaling; T cell activation; T cell mediated immunity
Research Articles on Cd8a
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Products associated with Cd8a elisa kit
Pathways associated with Cd8a elisa kit
Diseases associated with Cd8a elisa kit
Organs/Tissues associated with Cd8a elisa kit
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