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TRAIL/TNFSF10 elisa kit :: Rat TRAIL/TNFSF10 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2511036
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRAIL/TNFSF10, ELISA Kit

★Popular Item★
 Also Known As   

Rat TRAIL/TNFSF10 (Tumor Necrosis Factor Related Apoptosis Inducing Ligand) ELISA Kit

 Product Gene Name   

TRAIL/TNFSF10 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603598
 3D Structure    ModBase 3D Structure for P50591
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Rat TRAIL/TNFSF10. No significant cross-reactivity or interference between Rat TRAIL/TNFSF10 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat TRAIL/TNFSF10 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    15.625-1000pg/mL
 Sensitivity    Min: 9.375pg/mL; Max: 1000pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TRAIL/TNFSF10 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TRAIL/TNFSF10 purchase    MBS2511036 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TRAIL/TNFSF10, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.625-1000pg/mL in biological research samples containing TRAIL/TNFSF10, with an estimated sensitivity of Min: 9.375pg/mL; Max: 1000pg/mL. The ELISA analytical biochemical technique of the MBS2511036 kit is based on TRAIL/TNFSF10 antibody-TRAIL/TNFSF10 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TRAIL/TNFSF10 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TRAIL/TNFSF10. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TRAIL/TNFSF10 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of TRAIL/TNFSF10 in Rat serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat TRAIL/TNFSF10. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Rat TRAIL/TNFSF10 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat TRAIL/TNFSF10, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Rat TRAIL/TNFSF10. You can calculate the concentration of Rat TRAIL/TNFSF10 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of TRAIL/TNFSF10 elisa kit    TRAIL/TNFSF10 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2511036. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TRAIL/TNFSF10. It may not necessarily be applicable to this product.
 NCBI GI #    4507593
 NCBI GeneID    8743
 NCBI Accession #    NP_003801.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003810.3 [Other Products]
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 UniProt Primary Accession #    P50591 [Other Products]
 UniProt Secondary Accession #    A1Y9B3 [Other Products]
 UniProt Related Accession #    P50591 [Other Products]
 Molecular Weight    11,746 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 10 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 10
 NCBI Official Symbol    TNFSF10 [Similar Products]
 NCBI Official Synonym Symbols   
TL2; APO2L; CD253; TRAIL; Apo-2L
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; chemokine tumor necrosis factor ligand superfamily member 10; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 10
 UniProt Synonym Protein Names   
Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253
 UniProt Gene Name    TNFSF10 [Similar Products]
 UniProt Synonym Gene Names    APO2L; TRAIL; Apo-2L; Protein TRAIL [Similar Products]
 UniProt Entry Name    TNF10_HUMAN
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 NCBI Summary for TRAIL/TNFSF10    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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 UniProt Comments for TRAIL/TNFSF10    TRAIL: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Homotrimer. Widespread; most predominant in spleen, lung and prostate. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine

Chromosomal Location of Human Ortholog: 3q26

Cellular Component: extracellular space; integral to plasma membrane; extracellular region

Molecular Function: protein binding; metal ion binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: caspase activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; cell-cell signaling; apoptosis; positive regulation of apoptosis; male gonad development; positive regulation of caspase activity; immune response; signal transduction; response to insulin stimulus
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 Research Articles on TRAIL/TNFSF10    1. Data suggest that Src activates EGFR through the interaction of both Src-EGFR and Src-caveolin-1, and then antagonizes TRAIL-induced apoptosis in gastric cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TRAIL/TNFSF10 elisa kitPathways associated with TRAIL/TNFSF10 elisa kit
 Reference Product  PubMed Publications
 TNFRSF10B elisa kit  >2795 publications with TRAIL/TNFSF10 and TNFRSF10B
 CASP8 elisa kit  >1300 publications with TRAIL/TNFSF10 and CASP8
 FADD elisa kit  >637 publications with TRAIL/TNFSF10 and FADD
 TNFRSF10A elisa kit  >566 publications with TRAIL/TNFSF10 and TNFRSF10A
 CFLAR elisa kit  >256 publications with TRAIL/TNFSF10 and CFLAR
 TNFRSF11B elisa kit  >174 publications with TRAIL/TNFSF10 and TNFRSF11B
 TNFRSF10C elisa kit  >118 publications with TRAIL/TNFSF10 and TNFRSF10C
 TRADD elisa kit  >62 publications with TRAIL/TNFSF10 and TRADD
 CASP10 elisa kit  >62 publications with TRAIL/TNFSF10 and CASP10
 TNFRSF10D elisa kit  >52 publications with TRAIL/TNFSF10 and TNFRSF10D
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Caspase-8 Activation By Cleavage Pathway antibodies  Caspase-8 Activation By Cleavage Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Dimerization Of Procaspase-8 Pathway antibodies  Dimerization Of Procaspase-8 Pathway Diagram
Diseases associated with TRAIL/TNFSF10 elisa kitOrgans/Tissues associated with TRAIL/TNFSF10 elisa kit
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3860 publications with TRAIL/TNFSF10 and Necrosis
 Leukemia Antibodies  >471 publications with TRAIL/TNFSF10 and Leukemia
 Colorectal Neoplasms Antibodies  >343 publications with TRAIL/TNFSF10 and Colorectal Neoplasms
 Liver Diseases Antibodies  >340 publications with TRAIL/TNFSF10 and Liver Diseases
 Breast Neoplasms Antibodies  >318 publications with TRAIL/TNFSF10 and Breast Neoplasms
 Liver Neoplasms Antibodies  >297 publications with TRAIL/TNFSF10 and Liver Neoplasms
 Lung Neoplasms Antibodies  >292 publications with TRAIL/TNFSF10 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >287 publications with TRAIL/TNFSF10 and Neoplasms, Experimental
 Inflammation Antibodies  >275 publications with TRAIL/TNFSF10 and Inflammation
 Glioma Antibodies  >250 publications with TRAIL/TNFSF10 and Glioma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1116 publications with TRAIL/TNFSF10 and Blood
 Liver Antibodies  >464 publications with TRAIL/TNFSF10 and Liver
 Lung Antibodies  >393 publications with TRAIL/TNFSF10 and Lung
 Prostate Antibodies  >325 publications with TRAIL/TNFSF10 and Prostate
 Brain Antibodies  >234 publications with TRAIL/TNFSF10 and Brain
 Vascular Antibodies  >193 publications with TRAIL/TNFSF10 and Vascular
 Kidney Antibodies  >154 publications with TRAIL/TNFSF10 and Kidney
 Skin Antibodies  >128 publications with TRAIL/TNFSF10 and Skin
 Bone Marrow Antibodies  >113 publications with TRAIL/TNFSF10 and Bone Marrow
 Muscle Antibodies  >78 publications with TRAIL/TNFSF10 and Muscle
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