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TIMP-1 elisa kit :: Rat Tissue Inhibitors Of Metalloproteinase 1 (TIMP-1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS263032
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $275 +1 FREE 8GB USB
96-Strip-Wells  /  $435 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,755 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,150 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Inhibitors Of Metalloproteinase 1 (TIMP-1), ELISA Kit

★Popular Item★
 Also Known As   

Rat Tissue Inhibitors Of Metalloproteinase 1 (TIMP-1) ELISA Kit

 Product Gene Name   

TIMP-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    305370
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 Species Reactivity    Rat
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 Specificity    No cross-reaction with other factors.
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 Samples    Rat serum, plasma or cell culture supernatant
 Detection Range    10 ng/ml-0.156ng/ml
 Sensitivity    0.05 ng/mL
 Intra-assay Precision    ? 8%
 Inter-assay Precision    ? 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TIMP-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TIMP-1 purchase    MBS263032 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tissue Inhibitors Of Metalloproteinase 1 (TIMP-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10 ng/ml-0.156ng/ml in biological research samples containing TIMP-1, with an estimated sensitivity of 0.05 ng/mL. The ELISA analytical biochemical technique of the MBS263032 kit is based on TIMP-1 antibody-TIMP-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TIMP-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TIMP-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Rat serum, plasma or cell culture supernatant. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TIMP-1 elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Rat TIMP-1 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of TIMP-1 elisa kit    TIMP-1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS263032. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TIMP-1. It may not necessarily be applicable to this product.
 NCBI GI #    994731
 NCBI GeneID    7076
 NCBI Accession #    AAA75558.1 [Other Products]
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 UniProt Secondary Accession #    Q14252; Q9UCU1 [Other Products]
 UniProt Related Accession #    P01033 [Other Products]
 Molecular Weight    23,171 Da
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 NCBI Official Full Name    tissue inhibitor of metalloproteinase 1, partial
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 1
 NCBI Official Symbol    TIMP1 [Similar Products]
 NCBI Official Synonym Symbols   
EPA; EPO; HCI; CLGI; TIMP
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
 UniProt Protein Name    Metalloproteinase inhibitor 1
 UniProt Synonym Protein Names   
Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1
 UniProt Gene Name    TIMP1 [Similar Products]
 UniProt Synonym Gene Names    CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1 [Similar Products]
 UniProt Entry Name    TIMP1_HUMAN
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 NCBI Summary for TIMP-1    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP-1    TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp11.3-p11.23

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region; basement membrane

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; growth factor activity; protease binding; metal ion binding; cytokine activity

Biological Process: platelet activation; extracellular matrix disassembly; response to peptide hormone stimulus; extracellular matrix organization and biogenesis; negative regulation of metalloenzyme activity; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; response to hormone stimulus; blood coagulation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of apoptosis; aging
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 Research Articles on TIMP-1    1. These data indicated that TIMP-1 may be identified as a prognostic marker of laryngeal squamous cell carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TIMP-1 elisa kitPathways associated with TIMP-1 elisa kit
 Reference Product  PubMed Publications
 MMP2 elisa kit  >197 publications with TIMP-1 and MMP2
 MMP9 elisa kit  >191 publications with TIMP-1 and MMP9
 MMP1 elisa kit  >108 publications with TIMP-1 and MMP1
 MMP3 elisa kit  >60 publications with TIMP-1 and MMP3
 TGFB1 elisa kit  >47 publications with TIMP-1 and TGFB1
 MMP14 elisa kit  >19 publications with TIMP-1 and MMP14
 FN1 elisa kit  >8 publications with TIMP-1 and FN1
 EGF elisa kit  >6 publications with TIMP-1 and EGF
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with TIMP-1 elisa kitOrgans/Tissues associated with TIMP-1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >182 publications with TIMP-1 and Neoplasms
 Fibrosis Antibodies  >111 publications with TIMP-1 and Fibrosis
 Cardiovascular Diseases Antibodies  >94 publications with TIMP-1 and Cardiovascular Diseases
 Inflammation Antibodies  >94 publications with TIMP-1 and Inflammation
 Vascular Diseases Antibodies  >67 publications with TIMP-1 and Vascular Diseases
 Necrosis Antibodies  >59 publications with TIMP-1 and Necrosis
 Liver Diseases Antibodies  >56 publications with TIMP-1 and Liver Diseases
 Heart Diseases Antibodies  >47 publications with TIMP-1 and Heart Diseases
 Female Urogenital Diseases Antibodies  >42 publications with TIMP-1 and Female Urogenital Diseases
 Nervous System Diseases Antibodies  >36 publications with TIMP-1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >166 publications with TIMP-1 and Blood
 Vascular Antibodies  >86 publications with TIMP-1 and Vascular
 Liver Antibodies  >85 publications with TIMP-1 and Liver
 Lung Antibodies  >69 publications with TIMP-1 and Lung
 Muscle Antibodies  >65 publications with TIMP-1 and Muscle
 Bone Antibodies  >64 publications with TIMP-1 and Bone
 Heart Antibodies  >56 publications with TIMP-1 and Heart
 Kidney Antibodies  >46 publications with TIMP-1 and Kidney
 Connective Tissue Antibodies  >45 publications with TIMP-1 and Connective Tissue
 Skin Antibodies  >44 publications with TIMP-1 and Skin
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