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TFR2 elisa kit :: Rat Transferrin Receptor Protein 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS034083 TFR2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transferrin Receptor Protein 2 (TFR2), ELISA Kit

 Also Known As   

Rat Transferrin Receptor Protein 2 ELISA Kit

 Product Gene Name   

TFR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 7; NC_000007.13 (100218039..100239173, complement). Location: 7q22
 OMIM    604250
 3D Structure    ModBase 3D Structure for Q9UP52
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 Species Reactivity    Rat
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TFR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TFR2 purchase    MBS034083 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Transferrin Receptor Protein 2 (TFR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TFR2. The ELISA analytical biochemical technique of the MBS034083 kit is based on TFR2 antibody-TFR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TFR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TFR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TFR2. It may not necessarily be applicable to this product.
 NCBI GI #    332309171
 NCBI GeneID    7036
 NCBI Accession #    NP_001193784.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206855.1 [Other Products]
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 UniProt Primary Accession #    Q9UP52 [Other Products]
 UniProt Secondary Accession #    O75422; Q1HE13; Q9HA99; Q9NX67; A6NGM7 [Other Products]
 UniProt Related Accession #    Q9UP52 [Other Products]
 Molecular Weight    88,755 Da
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 NCBI Official Full Name    transferrin receptor protein 2 isoform 2
 NCBI Official Synonym Full Names    transferrin receptor 2
 NCBI Official Symbol    TFR2 [Similar Products]
 NCBI Official Synonym Symbols   
HFE3; TFRC2
[Similar Products]
 NCBI Protein Information    transferrin receptor protein 2
 UniProt Protein Name    Transferrin receptor protein 2
 Protein Family    Transferrin receptor protein
 UniProt Gene Name    TFR2 [Similar Products]
 UniProt Synonym Gene Names    TfR2 [Similar Products]
 UniProt Entry Name    TFR2_HUMAN
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 NCBI Summary for TFR2    This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
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 UniProt Comments for TFR2    TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 7q22

Cellular Component: integral to plasma membrane; cytoplasm

Molecular Function: transferrin receptor activity

Biological Process: receptor-mediated endocytosis; cellular iron ion homeostasis; iron ion transport

Disease: Hemochromatosis, Type 3
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 Research Articles on TFR2    1. The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TFR2 elisa kitPathways associated with TFR2 elisa kit
 Reference Product  PubMed Publications
 HFE elisa kit  >192 publications with TFR2 and HFE
 HAMP elisa kit  >56 publications with TFR2 and HAMP
 HFE2 elisa kit  >37 publications with TFR2 and HFE2
 SLC40A1 elisa kit  >33 publications with TFR2 and SLC40A1
 TMPRSS6 elisa kit  >7 publications with TFR2 and TMPRSS6
 FTL elisa kit  >6 publications with TFR2 and FTL
 CYBRD1 elisa kit  >1 publications with TFR2 and CYBRD1
 SLC11A2 elisa kit  >1 publications with TFR2 and SLC11A2
 Products by Pathway  Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
Diseases associated with TFR2 elisa kitOrgans/Tissues associated with TFR2 elisa kit
 Disease Name  Pubmed Publications
 Hemochromatosis Antibodies  >197 publications with TFR2 and Hemochromatosis
 Liver Diseases Antibodies  >49 publications with TFR2 and Liver Diseases
 Neoplasms Antibodies  >35 publications with TFR2 and Neoplasms
 Carcinoma, Hepatocellular Antibodies  >18 publications with TFR2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >16 publications with TFR2 and Liver Neoplasms
 Inflammation Antibodies  >13 publications with TFR2 and Inflammation
 beta-Thalassemia Antibodies  >8 publications with TFR2 and beta-Thalassemia
 Fibrosis Antibodies  >7 publications with TFR2 and Fibrosis
 Necrosis Antibodies  >5 publications with TFR2 and Necrosis
 Neurodegenerative Diseases Antibodies  >5 publications with TFR2 and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >136 publications with TFR2 and Liver
 Bone Antibodies  >22 publications with TFR2 and Bone
 Brain Antibodies  >8 publications with TFR2 and Brain
 Bone Marrow Antibodies  >3 publications with TFR2 and Bone Marrow
 Lung Antibodies  >2 publications with TFR2 and Lung
 Lymph Node Antibodies  >1 publications with TFR2 and Lymph Node
 Uncharacterized Tissue Antibodies  >1 publications with TFR2 and Uncharacterized Tissue
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