AAF13491.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,006 Da
NCBI Official Full Name
transforming growth factor-alpha
NCBI Official Synonym Full Names
transforming growth factor, alpha
NCBI Official Synonym Symbols
NCBI Protein Information
protransforming growth factor alpha; TGF-alpha
UniProt Protein Name
Protransforming growth factor alpha
UniProt Synonym Protein Names
EGF-like TGF; ETGF; TGF type 1
UniProt Synonym Gene Names
UniProt Entry Name
TGFA_HUMAN
NCBI Summary for TGFA
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Comments for TGFA
TGFalpha: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Ligand, receptor tyrosine kinase; Cell cycle regulation
Chromosomal Location of Human Ortholog: 2p13
Cellular Component: extracellular space; cell surface; perinuclear region of cytoplasm; integral to plasma membrane; basolateral plasma membrane; plasma membrane; cytoplasmic vesicle; nucleus
Molecular Function: protein binding; growth factor activity; glycoprotein binding; epidermal growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; response to drug; cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of mitosis; wound healing; activation of MAPK activity; angiogenesis; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
Research Articles on TGFA
Precautions
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Disclaimer
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Products associated with TGFA elisa kit
Pathways associated with TGFA elisa kit
Diseases associated with TGFA elisa kit
Organs/Tissues associated with TGFA elisa kit
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