NP_060106.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
134,301 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 4 isoform 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 4
NCBI Protein Information
transient receptor potential cation channel subfamily M member 4; LTrpC4; hTRPM4; melastatin-4; long transient receptor potential channel 4; calcium-activated non-selective cation channel 1
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 4
UniProt Synonym Protein Names
Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; Melastatin-4
UniProt Synonym Gene Names
UniProt Entry Name
TRPM4_HUMAN
NCBI Summary for TRPM1
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
UniProt Comments for TRPM1
TRPM4: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B). It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrioventricular block causing syncope and sudden death. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: calmodulin binding; calcium channel activity; calcium activated cation channel activity; ATP binding
Biological Process: vasoconstriction; regulation of membrane potential; protein sumoylation; regulation of T cell cytokine production; positive regulation of cell proliferation; dendritic cell chemotaxis; transmembrane transport
Disease: Progressive Familial Heart Block, Type Ib
Research Articles on TRPM1
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Products associated with TRPM1 elisa kit
Pathways associated with TRPM1 elisa kit
Diseases associated with TRPM1 elisa kit
Organs/Tissues associated with TRPM1 elisa kit
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