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TrxR1 elisa kit :: Rat TrxR1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2503329
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TrxR1, ELISA Kit

★Popular Item★
 Also Known As   

Rat TrxR1 (Thioredoxin Reductase 1) ELISA Kit

 Product Gene Name   

TrxR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    601112
 3D Structure    ModBase 3D Structure for Q16881
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Rat TrxR1. No significant cross-reactivity or interference between Rat TrxR1 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Rat TrxR1 and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    0.156-10ng/mL
 Sensitivity    Min: 0.094ng/mL; Max: 10ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TrxR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TrxR1 purchase    MBS2503329 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TrxR1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156-10ng/mL in biological research samples containing TrxR1, with an estimated sensitivity of Min: 0.094ng/mL; Max: 10ng/mL. The ELISA analytical biochemical technique of the MBS2503329 kit is based on TrxR1 antibody-TrxR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TrxR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TrxR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TrxR1 elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of TrxR1 in Rat serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Rat TrxR1. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Rat TrxR1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Rat TrxR1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Rat TrxR1. You can calculate the concentration of Rat TrxR1 in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of TrxR1 elisa kit    TrxR1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2503329. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TrxR1. It may not necessarily be applicable to this product.
 NCBI GI #    387598071
 NCBI GeneID    7296
 NCBI Accession #    NP_001248375.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001261446.1 [Other Products]
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 UniProt Primary Accession #    Q16881 [Other Products]
 UniProt Secondary Accession #    Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780 [Other Products]
 UniProt Related Accession #    Q16881 [Other Products]
 Molecular Weight    50,873 Da
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 NCBI Official Full Name    thioredoxin reductase 1, cytoplasmic isoform 5
 NCBI Official Synonym Full Names    thioredoxin reductase 1
 NCBI Official Symbol    TXNRD1 [Similar Products]
 NCBI Official Synonym Symbols   
TR; TR1; TXNR; TRXR1; GRIM-12
[Similar Products]
 NCBI Protein Information    thioredoxin reductase 1, cytoplasmic; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; oxidoreductase; thioredoxin reductase GRIM-12; thioredoxin reductase TR1
 UniProt Protein Name    Thioredoxin reductase 1, cytoplasmic
 UniProt Synonym Protein Names   
Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1
 UniProt Gene Name    TXNRD1 [Similar Products]
 UniProt Synonym Gene Names    GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein [Similar Products]
 UniProt Entry Name    TRXR1_HUMAN
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 NCBI Summary for TrxR1    This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TrxR1    TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.

Protein type: EC 1.8.1.9; Nuclear receptor co-regulator; Oxidoreductase; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: nucleoplasm; nucleolus; cytosol

Molecular Function: protein binding; thioredoxin-disulfide reductase activity; electron carrier activity; FAD binding; protein disulfide oxidoreductase activity

Biological Process: response to reactive oxygen species; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; cellular lipid metabolic process; signal transduction
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 Research Articles on TrxR1    1. Targeting TrxR1 with shikonin thus discloses a previously unrecognized mechanism underlying the biological activity of shikonin and provides an in-depth insight into the action of shikonin in the treatment of cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TrxR1 elisa kitDiseases associated with TrxR1 elisa kit
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >18 publications with TrxR1 and Liver Diseases
 Breast Neoplasms Antibodies  >13 publications with TrxR1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >13 publications with TrxR1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >12 publications with TrxR1 and Nervous System Diseases
 Liver Neoplasms Antibodies  >11 publications with TrxR1 and Liver Neoplasms
 Inflammation Antibodies  >9 publications with TrxR1 and Inflammation
 Necrosis Antibodies  >9 publications with TrxR1 and Necrosis
 Poisoning Antibodies  >8 publications with TrxR1 and Poisoning
 Lung Neoplasms Antibodies  >7 publications with TrxR1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >6 publications with TrxR1 and Carcinoma, Hepatocellular
Organs/Tissues associated with TrxR1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >45 publications with TrxR1 and Liver
 Blood Antibodies  >22 publications with TrxR1 and Blood
 Lung Antibodies  >20 publications with TrxR1 and Lung
 Kidney Antibodies  >13 publications with TrxR1 and Kidney
 Heart Antibodies  >13 publications with TrxR1 and Heart
 Muscle Antibodies  >13 publications with TrxR1 and Muscle
 Brain Antibodies  >12 publications with TrxR1 and Brain
 Prostate Antibodies  >10 publications with TrxR1 and Prostate
 Vascular Antibodies  >9 publications with TrxR1 and Vascular
 Skin Antibodies  >8 publications with TrxR1 and Skin
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