NP_570095.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,180 Da
NCBI Official Full Name
long-chain-fatty-acid--CoA ligase 6
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 6
NCBI Official Synonym Symbols
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 6; LACS 6; long-chain acyl-CoA synthetase 6; fatty acid Coenzyme A ligase, long chain 6; long-chain-fatty-acid--CoA ligase, brain isozyme
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 6
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 6; LACS 6; Long-chain-fatty-acid--CoA ligase, brain isozyme
UniProt Synonym Gene Names
UniProt Entry Name
ACSL6_RAT
NCBI Summary for ACSL6
catalyzes the ligation of long chain fatty acids with coenzyme A to produce long chain acyl-CoAs in fatty acid metabolism [RGD, Feb 2006]
UniProt Comments for ACSL6
ACSL6: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6. Belongs to the ATP-dependent AMP-binding enzyme family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral; EC 6.2.1.3
Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; membrane; integral to membrane; nucleus
Molecular Function: protein homodimerization activity; enzyme binding; catalytic activity; ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: response to gravity; triacylglycerol metabolic process; cellular response to insulin stimulus; metabolic process; response to steroid hormone stimulus; neuroblast proliferation; response to hypoxia; neuron development; long-chain fatty acid metabolic process; response to nutrient; fatty acid transport; phospholipid biosynthetic process
Research Articles on ACSL6
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Pathways associated with ACSL6 elisa kit
Diseases associated with ACSL6 elisa kit
Organs/Tissues associated with ACSL6 elisa kit
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