NP_001014202.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
34,011 Da
NCBI Official Full Name
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
NCBI Official Synonym Full Names
alkB, alkylation repair homolog 3 (E. coli)
NCBI Protein Information
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; AlkB homolog 3; alkylated DNA repair protein alkB homolog 3
UniProt Protein Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 3
UniProt Synonym Gene Names
UniProt Entry Name
ALKB3_RAT
UniProt Comments for ALKBH3
Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron
Cofactor: Binds 1 Fe2+ ion per subunit
Enzyme regulation: Activated by ascorbate
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Pathways associated with ALKBH3 elisa kit
Diseases associated with ALKBH3 elisa kit
Organs/Tissues associated with ALKBH3 elisa kit
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