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alpha1-AT elisa kit :: Rat alpha1 Antitrypsin ELISA Kit

Scan QR to view Datasheet Catalog #    MBS013664 alpha1-AT elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

alpha1 Antitrypsin (alpha1-AT), ELISA Kit

★Popular Item★
 Also Known As   

Rat alpha1 Antitrypsin ELISA Kit

 Product Gene Name   

alpha1-AT elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 14; NC_000014.8 (94843084..94857029, complement). Location: 14q32.1
 OMIM    107400
 3D Structure    ModBase 3D Structure for P01009
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 Species Reactivity    Rat
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
 Assay Type    Sandwich
 Detection Range    6.25 umol/L - 200 umol/L.
 Sensitivity    1.0 umol/L.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of alpha1-AT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for alpha1-AT purchase    MBS013664 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the alpha1 Antitrypsin (alpha1-AT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 6.25 umol/L - 200 umol/L in biological research samples containing alpha1-AT, with an estimated sensitivity of 1.0 umol/L. The ELISA analytical biochemical technique of the MBS013664 kit is based on alpha1-AT antibody-alpha1-AT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect alpha1-AT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, alpha1-AT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for alpha1-AT elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of A1AT (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS013664. Click to request current manual
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NCBI/Uniprot data below describe general gene information for alpha1-AT. It may not necessarily be applicable to this product.
 NCBI GI #    50363221
 NCBI GeneID    5265
 NCBI Accession #    NP_001002235.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002235.2 [Other Products]
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 UniProt Primary Accession #    P01009 [Other Products]
 UniProt Secondary Accession #    Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8 [Other Products]
 UniProt Related Accession #    P01009 [Other Products]
 Molecular Weight    46,737 Da
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 NCBI Official Full Name    alpha-1-antitrypsin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
 NCBI Official Symbol    SERPINA1 [Similar Products]
 NCBI Official Synonym Symbols   
PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT
[Similar Products]
 NCBI Protein Information    alpha-1-antitrypsin; serpin A1; alpha-1-antiproteinase; alpha-1-antitrypsin null; alpha-1 protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1
 UniProt Protein Name    Alpha-1-antitrypsin
 UniProt Synonym Protein Names   
Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
 UniProt Gene Name    SERPINA1 [Similar Products]
 UniProt Synonym Gene Names    AAT; PI; SPAAT [Similar Products]
 UniProt Entry Name    A1AT_HUMAN
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 NCBI Summary for alpha1-AT    The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for alpha1-AT    SERPINA1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: Golgi apparatus; proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding; protease binding; glycoprotein binding

Biological Process: platelet activation; response to chromate; platelet degranulation; response to triglyceride; response to cytokine stimulus; response to lead ion; acute-phase response; response to methanol; response to hypoxia; response to lipopolysaccharide; blood coagulation; response to estradiol stimulus

Disease: Alpha-1-antitrypsin Deficiency; Pulmonary Disease, Chronic Obstructive
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 Research Articles on alpha1-AT    1. TFEB gene transfer is a novel strategy for treatment of liver disease of alpha-1-anti-trypsin deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with alpha1-AT elisa kitDiseases associated with alpha1-AT elisa kit
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >110 publications with alpha1-AT and Lung Diseases
 alpha 1-Antitrypsin Deficiency Antibodies  >109 publications with alpha1-AT and alpha 1-Antitrypsin Deficiency
 Liver Diseases Antibodies  >101 publications with alpha1-AT and Liver Diseases
 Neoplasms Antibodies  >40 publications with alpha1-AT and Neoplasms
 Pulmonary Disease, Chronic Obstructive Antibodies  >38 publications with alpha1-AT and Pulmonary Disease, Chronic Obstructive
 Pulmonary Emphysema Antibodies  >30 publications with alpha1-AT and Pulmonary Emphysema
 Inflammation Antibodies  >29 publications with alpha1-AT and Inflammation
 Liver Cirrhosis Antibodies  >24 publications with alpha1-AT and Liver Cirrhosis
 Cardiovascular Diseases Antibodies  >24 publications with alpha1-AT and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >20 publications with alpha1-AT and Carcinoma, Hepatocellular
Organs/Tissues associated with alpha1-AT elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >97 publications with alpha1-AT and Liver
 Blood Antibodies  >84 publications with alpha1-AT and Blood
 Lung Antibodies  >57 publications with alpha1-AT and Lung
 Skin Antibodies  >13 publications with alpha1-AT and Skin
 Vascular Antibodies  >10 publications with alpha1-AT and Vascular
 Kidney Antibodies  >9 publications with alpha1-AT and Kidney
 Heart Antibodies  >9 publications with alpha1-AT and Heart
 Bone Antibodies  >7 publications with alpha1-AT and Bone
 Pancreas Antibodies  >7 publications with alpha1-AT and Pancreas
 Intestine Antibodies  >6 publications with alpha1-AT and Intestine
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