EFM18211.1
[Other Products]
Molecular Weight
24,045 Da
NCBI Official Full Name
anti sigma-E protein, RseA
UniProt Protein Name
Anti-sigma-E factor RseA
UniProt Synonym Protein Names
Regulator of SigE; Sigma-E anti-sigma factor RseA; Sigma-E factor negative regulatory protein
UniProt Entry Name
E0M2Z0_9ENTR
UniProt Comments for SCL70
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
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