NP_076469.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
141,152 Da
NCBI Official Full Name
apoptotic protease-activating factor 1
NCBI Official Synonym Full Names
apoptotic peptidase activating factor 1
NCBI Protein Information
apoptotic protease-activating factor 1; apaf-1; apoptotic protease activating factor 1
UniProt Protein Name
Apoptotic protease-activating factor 1
UniProt Synonym Gene Names
UniProt Entry Name
APAF_RAT
NCBI Summary for APAF1
protein involved in the initiation of apoptosis [RGD, Feb 2006]
UniProt Comments for APAF1
APAF: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Monomer. Oligomerizes upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain). By E2F and p53/TP53 in apoptotic neurons. Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Cellular Component: cytosol; nucleus; apoptosome
Molecular Function: identical protein binding; protein binding; heat shock protein binding; caspase activator activity; ADP binding; ATP binding
Biological Process: caspase activation; apoptosis; multicellular organismal development; neuron apoptosis; neural tube closure; forebrain development; response to hypoxia; caspase activation via cytochrome c; brain development; cell differentiation; response to nutrient; protein homooligomerization; aging
Research Articles on APAF1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with APAF1 elisa kit
Diseases associated with APAF1 elisa kit
Organs/Tissues associated with APAF1 elisa kit
|