Q9Y233.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,390 Da
NCBI Official Full Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
NCBI Official Synonym Full Names
phosphodiesterase 10A
NCBI Official Synonym Symbols
NCBI Protein Information
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); phosphodiesterase 10A1 (PDE10A1)
UniProt Protein Name
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
UniProt Entry Name
PDE10_HUMAN
NCBI Summary for cGMP
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for cGMP
PDE10A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17; EC 3.1.4.35
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cGMP binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
Biological Process: cAMP catabolic process; cGMP catabolic process; blood coagulation; signal transduction
Research Articles on cGMP
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Products associated with cGMP elisa kit
Pathways associated with cGMP elisa kit
Diseases associated with cGMP elisa kit
Organs/Tissues associated with cGMP elisa kit
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