NP_036966.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
82,664 Da
NCBI Official Full Name
cartilage oligomeric matrix protein
NCBI Official Synonym Full Names
cartilage oligomeric matrix protein
NCBI Protein Information
cartilage oligomeric matrix protein
UniProt Protein Name
Cartilage oligomeric matrix protein
UniProt Synonym Gene Names
UniProt Entry Name
COMP_RAT
NCBI Summary for COMP
extracellular matrix protein that interacts with fibronectin and may play a role in extracellular matrix assembly and molecular interactions [RGD, Feb 2006]
UniProt Comments for COMP
Function: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.1 PublicationManual assertion based on experiment in:Ref.2
Cofactor: Binds 11-14 calcium ions per subunit
Research Articles on COMP
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Disclaimer
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Products associated with COMP elisa kit
Pathways associated with COMP elisa kit
Diseases associated with COMP elisa kit
Organs/Tissues associated with COMP elisa kit
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