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COX-2 elisa kit :: Rat cyclooxygenase-2 (COX-2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS266603
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $275 +1 FREE 8GB USB
96-Strip-Wells  /  $435 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,755 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,150 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cyclooxygenase-2 (COX-2), ELISA Kit

★Popular Item★
 Also Known As   

Rat cyclooxygenase-2 (COX-2) ELISA Kit

 Product Gene Name   

COX-2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    600262
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 Species Reactivity    Rat
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 Specificity    No cross-reaction with other factors.
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 Samples    Rat serum, plasma or cell culture supernatant
 Detection Range    10 ng/ml-0.156 ng/ml
 Sensitivity    0.05 ng/mL
 Intra-assay Precision    ? 8%
 Inter-assay Precision    ? 12%
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of COX-2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for COX-2 purchase    MBS266603 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cyclooxygenase-2 (COX-2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 10 ng/ml-0.156 ng/ml in biological research samples containing COX-2, with an estimated sensitivity of 0.05 ng/mL. The ELISA analytical biochemical technique of the MBS266603 kit is based on COX-2 antibody-COX-2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COX-2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COX-2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Rat serum, plasma or cell culture supernatant. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for COX-2 elisa kit

   Principle of the Assay: This experiment use double-sandwich elisa technique and the ELISA Kit provided is typical. The pre-coated antibody is Rat COX-2 monoclonal antibody and the detecting antibody is polyclonal antibody with biotin labeled. Samples and biotin labeling antibody are added into ELISA plate wells and washed out with PBS or TBS. Then Avidin-peroxidase conjugates are added to ELISA wells in order; Use TMB substrate for coloring after reactant thoroughly washed out by PBS or TBS. TMB turns into blue in peroxidase catalytic and finally turns into yellow under the action of acid. The color depth and the testing factors in samples are positively correlated.
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 Typical Testing Data/Standard Curve (for reference only) of COX-2 elisa kit    COX-2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS266603. Click to request current manual
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NCBI/Uniprot data below describe general gene information for COX-2. It may not necessarily be applicable to this product.
 NCBI GI #    9230775
 NCBI GeneID    5743
 NCBI Accession #    AAF85977.1 [Other Products]
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 UniProt Secondary Accession #    Q16876; A8K802 [Other Products]
 UniProt Related Accession #    P35354 [Other Products]
 Molecular Weight    68,996 Da
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 NCBI Official Full Name    cyclooxygenase-2, partial
 NCBI Official Synonym Full Names    prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
 NCBI Official Symbol    PTGS2 [Similar Products]
 NCBI Official Synonym Symbols   
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
[Similar Products]
 NCBI Protein Information    prostaglandin G/H synthase 2; PHS II; PGH synthase 2; cyclooxygenase 2b; prostaglandin H2 synthase 2
 UniProt Protein Name    Prostaglandin G/H synthase 2
 UniProt Synonym Protein Names   
Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
 UniProt Gene Name    PTGS2 [Similar Products]
 UniProt Synonym Gene Names    COX2; COX-2; PGH synthase 2; PGHS-2 [Similar Products]
 UniProt Entry Name    PGH2_HUMAN
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 NCBI Summary for COX-2    Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
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 UniProt Comments for COX-2    COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family.

Protein type: EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q25.2-q25.3

Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cytoplasm; caveola; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; protein homodimerization activity; enzyme binding; peroxidase activity; arachidonate 15-lipoxygenase activity; metal ion binding; heme binding; lipid binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to lithium ion; response to glucocorticoid stimulus; positive regulation of NF-kappaB import into nucleus; response to lipopolysaccharide; decidualization; sensory perception of pain; prostaglandin biosynthetic process; negative regulation of synaptic transmission, dopaminergic; positive regulation of synaptic transmission, glutamatergic; response to estradiol stimulus; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; response to vitamin D; lipoxygenase pathway; nicotinamide metabolic process; negative regulation of smooth muscle contraction; regulation of blood pressure; arachidonic acid metabolic process; positive regulation of smooth muscle contraction; angiogenesis; inflammatory response; response to fructose stimulus; water-soluble vitamin metabolic process; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; vitamin metabolic process; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; prostaglandin metabolic process; hair cycle; response to manganese ion; ovulation; NAD metabolic process; regulation of inflammatory response; positive regulation of fever; positive regulation of vasoconstriction; brown fat cell differentiation; response to oxidative stress; cell motility; embryo implantation
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 Research Articles on COX-2    1. Data indicate that Protectin DX inhibited both cyclooxygenase-1 and -2 (COX-1 and COX-2) in neutrophils.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COX-2 elisa kitPathways associated with COX-2 elisa kit
 Reference Product  PubMed Publications
 JUN elisa kit  >2545 publications with COX-2 and JUN
 PLA2G4A elisa kit  >273 publications with COX-2 and PLA2G4A
 ALOX5 elisa kit  >255 publications with COX-2 and ALOX5
 MAPK1 elisa kit  >235 publications with COX-2 and MAPK1
 FOS elisa kit  >213 publications with COX-2 and FOS
 PTGES elisa kit  >39 publications with COX-2 and PTGES
 CYP2E1 elisa kit  >30 publications with COX-2 and CYP2E1
 CAV1 elisa kit  >10 publications with COX-2 and CAV1
 MAPK14 elisa kit  >7 publications with COX-2 and MAPK14
 PTGDS elisa kit  >3 publications with COX-2 and PTGDS
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
Diseases associated with COX-2 elisa kitOrgans/Tissues associated with COX-2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6426 publications with COX-2 and Neoplasms
 Inflammation Antibodies  >5468 publications with COX-2 and Inflammation
 Carcinoma Antibodies  >2843 publications with COX-2 and Carcinoma
 Nervous System Diseases Antibodies  >2027 publications with COX-2 and Nervous System Diseases
 Drug Toxicity Antibodies  >1717 publications with COX-2 and Drug Toxicity
 Colorectal Neoplasms Antibodies  >1580 publications with COX-2 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1346 publications with COX-2 and Adenocarcinoma
 Skin Diseases Antibodies  >1054 publications with COX-2 and Skin Diseases
 Lung Diseases Antibodies  >928 publications with COX-2 and Lung Diseases
 Colonic Neoplasms Antibodies  >892 publications with COX-2 and Colonic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4288 publications with COX-2 and Blood
 Vascular Antibodies  >2903 publications with COX-2 and Vascular
 Brain Antibodies  >1798 publications with COX-2 and Brain
 Lung Antibodies  >1431 publications with COX-2 and Lung
 Muscle Antibodies  >1271 publications with COX-2 and Muscle
 Liver Antibodies  >1256 publications with COX-2 and Liver
 Stomach Antibodies  >1155 publications with COX-2 and Stomach
 Kidney Antibodies  >1148 publications with COX-2 and Kidney
 Bone Antibodies  >1052 publications with COX-2 and Bone
 Intestine Antibodies  >939 publications with COX-2 and Intestine
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