NP_113893.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,815 Da
NCBI Official Full Name
dihydropyrimidinase
NCBI Official Synonym Full Names
dihydropyrimidinase
NCBI Protein Information
dihydropyrimidinase; DHP; DHPase; hydantoinase; dihydropyrimidine amidohydrolase
UniProt Protein Name
Dihydropyrimidinase
UniProt Synonym Protein Names
Dihydropyrimidine amidohydrolase; Hydantoinase
UniProt Synonym Gene Names
UniProt Entry Name
DPYS_RAT
NCBI Summary for DPYS
enzyme thatcatalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism [RGD, Feb 2006]
UniProt Comments for DPYS
DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Protein type: Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Other Amino Acids Metabolism - beta-alanine; EC 3.5.2.2; Hydrolase
Cellular Component: cytosol
Molecular Function: thymine binding; amino acid binding; dihydropyrimidinase activity; uracil binding; zinc ion binding; phosphoprotein binding
Biological Process: uracil metabolic process; beta-alanine metabolic process; uracil catabolic process; thymine catabolic process; pyrimidine base catabolic process; protein homooligomerization; protein homotetramerization
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Pathways associated with DPYS elisa kit
Diseases associated with DPYS elisa kit
Organs/Tissues associated with DPYS elisa kit
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