NP_446104.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
153,317 Da
NCBI Official Full Name
vascular endothelial growth factor receptor 3
NCBI Official Synonym Full Names
fms-related tyrosine kinase 4
NCBI Official Synonym Symbols
NCBI Protein Information
vascular endothelial growth factor receptor 3; FLT-4; VEGFR-3; FMS-like tyrosine kinase 4; tyrosine-protein kinase receptor FLT4
UniProt Protein Name
Vascular endothelial growth factor receptor 3
UniProt Synonym Protein Names
Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
UniProt Synonym Gene Names
UniProt Entry Name
VGFR3_RAT
NCBI Summary for FLT4
VEGF receptor-related, cell surface associated kinase with growth promoting ability [RGD, Feb 2006]
UniProt Comments for FLT4
Function: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues
Research Articles on FLT4
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Products associated with FLT4 elisa kit
Pathways associated with FLT4 elisa kit
Diseases associated with FLT4 elisa kit
Organs/Tissues associated with FLT4 elisa kit
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