NP_074056.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
83,266 Da
NCBI Official Full Name
gephyrin
NCBI Official Synonym Full Names
gephyrin
NCBI Official Synonym Symbols
NCBI Protein Information
gephyrin; gephyrin isoform; putative glycine receptor-tubulin linker protein
UniProt Protein Name
Gephyrin
UniProt Synonym Protein Names
Putative glycine receptor-tubulin linker proteinIncluding the following 2 domains:Molybdopterin adenylyltransferase (EC:2.7.7.75); MPT adenylyltransferaseAlternative name(s):Domain G
UniProt Synonym Gene Names
UniProt Entry Name
GEPH_RAT
NCBI Summary for GPHN
plays a role in molybdenum cofactor biosynthesis; may play a role in membrane protein-cytoskeleton interactions [RGD, Feb 2006]
UniProt Comments for GPHN
gephyrin: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Homotrimer. Interacts with GABARAP. Inhibited by copper and tungsten. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75
Cellular Component: postsynaptic membrane; cytoskeleton; cytoplasm; synapse; intracellular; cell junction
Molecular Function: protein binding, bridging; tubulin binding; protein binding; protein homodimerization activity; metal ion binding; protein complex scaffold; ATP binding; receptor binding
Biological Process: establishment of protein localization; molybdenum incorporation into molybdenum-molybdopterin complex; synaptogenesis; establishment of synaptic specificity at neuromuscular junction; Mo-molybdopterin cofactor biosynthetic process; protein homooligomerization; protein targeting
Research Articles on GPHN
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Pathways associated with GPHN elisa kit
Diseases associated with GPHN elisa kit
Organs/Tissues associated with GPHN elisa kit
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