Q9W7C5
[Other Products]
UniProt Related Accession #
Molecular Weight
22,541 Da
NCBI Official Full Name
heparin-binding EGF-like growth factor
NCBI Official Synonym Full Names
heparin-binding EGF-like growth factor
NCBI Official Synonym Symbols
NCBI Protein Information
proheparin-binding EGF-like growth factor
UniProt Protein Name
Proheparin-binding EGF-like growth factor
UniProt Synonym Gene Names
UniProt Entry Name
HBEGF_CHICK
UniProt Comments for HB-EGF
Function: May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF
By similarity. Plays an important role in the proper development of cranial nerves by inhibting the migration of the cranial neural crest cells (NCCs) migration into the odd-numbered neuromeres (r3 and r5) of the hindbrain. Plays a role in mediating v-Jun-induced oncogenic transformation. Ref.1 Ref.2
Subunit structure: Interacts with CNIH2. Ref.2
Subcellular location: Heparin-binding EGF-like growth factor: Secreted › extracellular space
By similarity. Note: Mature HB-EGF is released into the extracellular space and probably binds to a receptor
By similarity.Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein
Developmental stage: Expressed uniformly in the embryonic hindbrain. Ref.2
Induction: Strongly induced in embryonic fibroblasts transformed by v-Jun. Ref.1
Sequence similarities: Contains 1 EGF-like domain.
Research Articles on HB-EGF
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with HB-EGF elisa kit
Diseases associated with HB-EGF elisa kit
Organs/Tissues associated with HB-EGF elisa kit
|