NP_001076176.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
126,142 Da
NCBI Official Full Name
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
NCBI Official Synonym Symbols
NCBI Protein Information
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; HAC-4; hyperpolarization activated cation channel; hyperpolarization-activated cation channel 4
UniProt Protein Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProt Synonym Protein Names
Hyperpolarization-activated cation channel 4; HAC-4
UniProt Synonym Gene Names
UniProt Entry Name
HCN4_RABIT
UniProt Comments for HCN4
Function: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.1 PublicationManual assertion based on experiment in:Ref.1
Enzyme regulation: Activated by cAMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening.1 PublicationManual assertion based on experiment in:Ref.1
Research Articles on HCN4
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Diseases associated with HCN4 elisa kit
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