NP_077335.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,319 Da
NCBI Official Full Name
hypoxia-inducible factor 1-alpha
NCBI Official Synonym Full Names
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
NCBI Official Synonym Symbols
NCBI Protein Information
hypoxia-inducible factor 1-alpha; HIF1 alpha; HIF1-alpha; HIF-1 alpha; HIF-1-alpha; hypoxia-inducible factor 1 alpha; hypoxia inducible factor 1, alpha subunit
UniProt Protein Name
Hypoxia-inducible factor 1-alpha
UniProt Synonym Gene Names
UniProt Entry Name
HIF1A_RAT
NCBI Summary for HIF1A
regulates transcription in response to low oxygen; may play a role in vascular biology [RGD, Feb 2006]
UniProt Comments for HIF1A
Function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia
Research Articles on HIF1A
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Products associated with HIF1A elisa kit
Pathways associated with HIF1A elisa kit
Diseases associated with HIF1A elisa kit
Organs/Tissues associated with HIF1A elisa kit
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