NP_071787.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
28,232 Da
NCBI Official Full Name
insulin-induced gene 1 protein
NCBI Official Synonym Full Names
insulin induced gene 1
NCBI Protein Information
insulin-induced gene 1 protein; INSIG-1; immediate-early protein CL-6; growth response protein (CL-6); insulin-induced growth response protein CL-6
UniProt Protein Name
Insulin-induced gene 1 protein
UniProt Synonym Protein Names
Immediate-early protein CL-6; Insulin-induced growth response protein CL-6
UniProt Synonym Gene Names
UniProt Entry Name
INSI1_RAT
NCBI Summary for INSIG1
insulin-induced growth response gene; may play a role in regulating intracellular cholesterol concentrations [RGD, Feb 2006]
UniProt Comments for INSIG1
Function: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth
Research Articles on INSIG1
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Diseases associated with INSIG1 elisa kit
Organs/Tissues associated with INSIG1 elisa kit
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