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KMO elisa kit :: Rat kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS941871
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (KMO), ELISA Kit

★Popular Item★
 Also Known As   

Rat Kynurenine 3-monooxygenase, KMO ELISA Kit

 Product Synonym Names    Rat Kynurenine 3-monooxygenase (KMO) ELISA kit; RP1-317G22.1; dJ317G22.1; kynurenine 3-hydroxylase; kynurenine 3-monooxygenase; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 Product Gene Name   

KMO elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS941871 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for O88867
 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of rat KMO. No significant cross-reactivity or interference between rat KMO and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, cell lysates
 Assay Type    Quantitative Sandwich
 Detection Range    15.6 pg/ml -1000 pg/ml
 Sensitivity    Typically less than 3.9 pg/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KMO elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KMO purchase    MBS941871 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (KMO) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 15.6 pg/ml -1000 pg/ml in biological research samples containing KMO, with an estimated sensitivity of Typically less than 3.9 pg/ml. The ELISA analytical biochemical technique of the MBS941871 kit is based on KMO antibody-KMO antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KMO antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KMO. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for KMO elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for KMO has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any KMO present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KMO is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KMO bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of KMO elisa kit    KMO elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS941871. Click to request current manual
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NCBI/Uniprot data below describe general gene information for KMO. It may not necessarily be applicable to this product.
 NCBI GI #    11024672
 NCBI GeneID    59113
 NCBI Accession #    NP_067604.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021593.1 [Other Products]
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 UniProt Primary Accession #    O88867 [Other Products]
 UniProt Related Accession #    O88867 [Other Products]
 Molecular Weight    54,353 Da
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 NCBI Official Full Name    kynurenine 3-monooxygenase
 NCBI Official Synonym Full Names    kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 NCBI Official Symbol    Kmo [Similar Products]
 NCBI Protein Information    kynurenine 3-monooxygenase; kynurenine 3-hydroxylase
 UniProt Protein Name    Kynurenine 3-monooxygenase
 UniProt Synonym Protein Names   
Kynurenine 3-hydroxylase
 UniProt Gene Name    Kmo [Similar Products]
 UniProt Entry Name    KMO_RAT
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 NCBI Summary for KMO    human homolog is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of L-kynurenine to form L-3-hydroxykynurenine [RGD, Feb 2006]
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 UniProt Comments for KMO    KMO: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; Oxidoreductase; Amino Acid Metabolism - tryptophan; EC 1.14.13.9

Cellular Component: mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: FAD binding; NAD(P)H oxidase activity; kynurenine 3-monooxygenase activity

Biological Process: anthranilate metabolic process; tryptophan catabolic process to kynurenine; NAD metabolic process; quinolinate biosynthetic process; response to salt stress
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with KMO elisa kitDiseases associated with KMO elisa kit
 Products by Pathway  Pathway Diagram
 Folic Acid Network Pathway antibodies  Folic Acid Network Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >25 publications with KMO and Mental Disorders
 Brain Diseases Antibodies  >15 publications with KMO and Brain Diseases
 Neoplasms Antibodies  >13 publications with KMO and Neoplasms
 Nervous System Diseases Antibodies  >11 publications with KMO and Nervous System Diseases
 Inflammation Antibodies  >5 publications with KMO and Inflammation
 Cognition Disorders Antibodies  >4 publications with KMO and Cognition Disorders
 Anemia Antibodies  >3 publications with KMO and Anemia
 Lymphoma Antibodies  >3 publications with KMO and Lymphoma
 Hematologic Diseases Antibodies  >3 publications with KMO and Hematologic Diseases
 Infection Antibodies  >3 publications with KMO and Infection
Organs/Tissues associated with KMO elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with KMO and Liver
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