NP_068526.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
22,900 Da
NCBI Official Full Name
protein lin-7 homolog B
NCBI Official Synonym Full Names
lin-7 homolog B (C. elegans)
NCBI Protein Information
protein lin-7 homolog B; MALS-2; lin-7B; lin-7-A; veli-2 protein; lin 7 homolog b; vertebrate lin-7 homolog 2; mammalian lin-seven protein 2; vertebrate homolog of C. elegans Lin-7 type 2
UniProt Protein Name
Protein lin-7 homolog B
UniProt Synonym Protein Names
Mammalian lin-seven protein 2; MALS-2; Vertebrate lin-7 homolog 2; Veli-2
UniProt Synonym Gene Names
UniProt Entry Name
LIN7B_RAT
NCBI Summary for LIN7B
one of several homologs of C.elegans lin-7; localizes to junctional complexes and synaptic junctions; may play a role in formation of cell-cell junctions [RGD, Feb 2006]
UniProt Comments for LIN7B
LIN7B: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface. Belongs to the lin-7 family. 2 isoforms of the human protein are produced by alternative splicing.
Cellular Component: postsynaptic membrane; neuron projection; tight junction; cell; basolateral plasma membrane; postsynaptic density; plasma membrane; synapse; intercellular junction
Molecular Function: protein domain specific binding; protein binding; PDZ domain binding
Biological Process: asymmetric protein localization; intercellular junction assembly; protein transport; exocytosis; neurotransmitter secretion; maintenance of epithelial cell polarity
Research Articles on LIN7B
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Diseases associated with LIN7B elisa kit
Organs/Tissues associated with LIN7B elisa kit
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