Q8R500.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,123 Da
NCBI Official Full Name
Mitofusin-2
NCBI Official Synonym Full Names
mitofusin 2
NCBI Official Synonym Symbols
NCBI Protein Information
mitofusin-2; transmembrane GTPase MFN2; hypertension-related protein; mitochondrial transmembrane GTPase FZO1A
UniProt Protein Name
Mitofusin-2
UniProt Synonym Protein Names
Mitochondrial transmembrane GTPase FZO1A; Protein HSG; Transmembrane GTPase MFN2
UniProt Synonym Gene Names
UniProt Entry Name
MFN2_RAT
UniProt Comments for MFN2
MFN2: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). CMT2A2 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6); also referred to as autosomal dominant hereditary motor and sensory neuropathy VI (HMSN6). CMT6 is an autosomal dominant form of axonal CMT associated with optic atrophy. Belongs to the mitofusin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Hydrolase; Mitochondrial; EC 3.6.5.-; Membrane protein, multi-pass; Membrane protein, integral; Cytoskeletal
Cellular Component: microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion; integral to membrane; cytosol; intrinsic to mitochondrial outer membrane
Molecular Function: GTPase activity; GTPase binding; GTP binding; ubiquitin protein ligase binding
Biological Process: mitochondrial fusion; apoptosis; negative regulation of smooth muscle cell proliferation; metabolic process; mitochondrial membrane organization and biogenesis; blastocyst formation; mitochondrion localization; response to unfolded protein; negative regulation of cell proliferation; camera-type eye morphogenesis; negative regulation of Ras protein signal transduction; autophagy; cell cycle arrest; protein targeting to mitochondrion
Research Articles on MFN2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with MFN2 elisa kit
Pathways associated with MFN2 elisa kit
Organs/Tissues associated with MFN2 elisa kit
|