NP_640346.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
16,148 Da
NCBI Official Full Name
multiple coagulation factor deficiency protein 2 homolog
NCBI Official Synonym Full Names
multiple coagulation factor deficiency 2
NCBI Official Synonym Symbols
NCBI Protein Information
multiple coagulation factor deficiency protein 2 homolog; stem cell derived neuronal survival protein; neural stem cell-derived neuronal survival protein
UniProt Protein Name
Multiple coagulation factor deficiency protein 2 homolog
UniProt Synonym Protein Names
Neural stem cell-derived neuronal survival protein
UniProt Synonym Gene Names
UniProt Entry Name
MCFD2_RAT
NCBI Summary for MCFD2
a survival factor involved in maintaining stem cell potential and lifelong neurogenesis in the adult central nervous system [RGD, Feb 2006]
UniProt Comments for MCFD2
MCFD2: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum
Cellular Component: Golgi apparatus; endoplasmic reticulum; ER-Golgi intermediate compartment; extracellular region
Molecular Function: calcium ion binding
Biological Process: vesicle-mediated transport; protein transport; carboxylic acid metabolic process
Research Articles on MCFD2
Precautions
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Disclaimer
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Pathways associated with MCFD2 elisa kit
Diseases associated with MCFD2 elisa kit
Disease Name |
Pubmed Publications |
FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 2 Antibodies |
>17 publications with MCFD2 and FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 2 |
FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 1 Antibodies |
>13 publications with MCFD2 and FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 1 |
Hemorrhage Antibodies |
>7 publications with MCFD2 and Hemorrhage |
Disease Models, Animal Antibodies |
>2 publications with MCFD2 and Disease Models, Animal |
Anemia Antibodies |
>2 publications with MCFD2 and Anemia |
Ovarian Diseases Antibodies |
>1 publications with MCFD2 and Ovarian Diseases |
Brain Diseases Antibodies |
>1 publications with MCFD2 and Brain Diseases |
Organs/Tissues associated with MCFD2 elisa kit
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