NP_113713.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
122,828 Da
NCBI Official Full Name
platelet-derived growth factor receptor beta
NCBI Official Synonym Full Names
platelet derived growth factor receptor, beta polypeptide
NCBI Official Synonym Symbols
NCBI Protein Information
platelet-derived growth factor receptor beta; PDGFR-beta; PDGF-R-beta; CD140 antigen-like family member B; platelet-derived growth factor receptor 1; beta platelet-derived growth factor receptor; Platelet-derived growth factor receptor, beta; beta-type platelet-derived growth factor receptor; platelet-derived growth factor receptor beta variant 1
UniProt Protein Name
Platelet-derived growth factor receptor beta
UniProt Synonym Protein Names
Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD_antigen: CD140b
UniProt Synonym Gene Names
UniProt Entry Name
PGFRB_RAT
NCBI Summary for p-ERK
binds platelet derived growth factor BB homodimer [RGD, Feb 2006]
UniProt Comments for p-ERK
PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.
Protein type: Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; TK group; PDGFR family
Research Articles on p-ERK
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Pathways associated with p-ERK elisa kit
Diseases associated with p-ERK elisa kit
Organs/Tissues associated with p-ERK elisa kit
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