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PAI-1 elisa kit :: Rat plasminogen activator inhibitor 1, PAI-1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9300198 PAI-1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

plasminogen activator inhibitor 1, PAI-1, ELISA Kit

 Also Known As   

Rat plasminogen activator inhibitor 1, PAI-1 ELISA Kit

 Product Gene Name   

PAI-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 Chromosome Location    Chromosome: 7; NC_000007.13 (100770370..100782547). Location: 7q22.1
 OMIM    173360
 3D Structure    ModBase 3D Structure for P05121
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 Species Reactivity    Rat
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich
 Detection Range    0.625 ng/ml - 20 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of PAI-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PAI-1 purchase    MBS9300198 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the plasminogen activator inhibitor 1, PAI-1, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.625 ng/ml - 20 ng/ml in biological research samples containing PAI-1, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9300198 kit is based on PAI-1 antibody-PAI-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PAI-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PAI-1. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions such as Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for PAI-1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PAI1 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This k it i s NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9300198
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NCBI/Uniprot data below describe general gene information for PAI-1. It may not necessarily be applicable to this product.
 NCBI GI #    10835159
 NCBI GeneID    5054
 NCBI Accession #    NP_000593.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000602.4 [Other Products]
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 UniProt Primary Accession #    P05121 [Other Products]
 UniProt Secondary Accession #    B7Z4S0; F8WD53 [Other Products]
 UniProt Related Accession #    P05121 [Other Products]
 Molecular Weight    45,060 Da
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 NCBI Official Full Name    plasminogen activator inhibitor 1
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 NCBI Official Symbol    SERPINE1 [Similar Products]
 NCBI Official Synonym Symbols   
PAI; PAI1; PAI-1; PLANH1
[Similar Products]
 NCBI Protein Information    plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 UniProt Protein Name    Plasminogen activator inhibitor 1
 UniProt Synonym Protein Names   
Endothelial plasminogen activator inhibitor; Serpin E1
 UniProt Gene Name    SERPINE1 [Similar Products]
 UniProt Synonym Gene Names    PAI1; PLANH1; PAI; PAI-1 [Similar Products]
 UniProt Entry Name    PAI1_HUMAN
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 NCBI Summary for PAI-1    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for PAI-1    SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular matrix; extracellular space; extracellular region; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; receptor binding

Biological Process: circadian rhythm; transcription initiation from RNA polymerase II promoter; platelet activation; extracellular matrix organization and biogenesis; positive regulation of blood coagulation; transcription, DNA-dependent; negative regulation of blood coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; positive regulation of receptor-mediated endocytosis; regulation of cell proliferation; positive regulation of interleukin-8 production; fibrinolysis; positive regulation of angiogenesis; negative regulation of fibrinolysis; platelet degranulation; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; regulation of receptor activity; chronological cell aging; blood coagulation; negative regulation of cell migration; negative regulation of cell adhesion mediated by integrin; positive regulation of inflammatory response

Disease: Plasminogen Activator Inhibitor-1 Deficiency
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 Research Articles on PAI-1    1. this data suggest a protective role for the 4G allele against pleuritis in Familial Mediterranean Fever patients with M694V homozygous mutation in this cohort.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAI-1 elisa kitPathways associated with PAI-1 elisa kit
 Reference Product  PubMed Publications
 TGFB1 elisa kit  >478 publications with PAI-1 and TGFB1
 SMAD4 elisa kit  >77 publications with PAI-1 and SMAD4
 EGF elisa kit  >59 publications with PAI-1 and EGF
 HIF1A elisa kit  >59 publications with PAI-1 and HIF1A
 PLG elisa kit  >41 publications with PAI-1 and PLG
 PLAT elisa kit  >22 publications with PAI-1 and PLAT
 PLAU elisa kit  >11 publications with PAI-1 and PLAU
 VTN elisa kit  >5 publications with PAI-1 and VTN
 ALB elisa kit  >3 publications with PAI-1 and ALB
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
Diseases associated with PAI-1 elisa kitOrgans/Tissues associated with PAI-1 elisa kit
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2997 publications with PAI-1 and Cardiovascular Diseases
 Neoplasms Antibodies  >1340 publications with PAI-1 and Neoplasms
 Thrombosis Antibodies  >1303 publications with PAI-1 and Thrombosis
 Inflammation Antibodies  >1158 publications with PAI-1 and Inflammation
 Heart Diseases Antibodies  >993 publications with PAI-1 and Heart Diseases
 Necrosis Antibodies  >784 publications with PAI-1 and Necrosis
 Atherosclerosis Antibodies  >727 publications with PAI-1 and Atherosclerosis
 Hypertension Antibodies  >652 publications with PAI-1 and Hypertension
 Fibrosis Antibodies  >609 publications with PAI-1 and Fibrosis
 Kidney Diseases Antibodies  >492 publications with PAI-1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2651 publications with PAI-1 and Vascular
 Liver Antibodies  >551 publications with PAI-1 and Liver
 Lung Antibodies  >527 publications with PAI-1 and Lung
 Embryonic Tissue Antibodies  >322 publications with PAI-1 and Embryonic Tissue
 Umbilical Cord Antibodies  >206 publications with PAI-1 and Umbilical Cord
 Skin Antibodies  >180 publications with PAI-1 and Skin
 Placenta Antibodies  >121 publications with PAI-1 and Placenta
 Intestine Antibodies  >67 publications with PAI-1 and Intestine
 Pancreas Antibodies  >39 publications with PAI-1 and Pancreas
 Amniotic Fluid Antibodies  >12 publications with PAI-1 and Amniotic Fluid
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