NP_001014175.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
78,346 Da
NCBI Official Full Name
protein arginine N-methyltransferase 7
NCBI Official Synonym Full Names
protein arginine methyltransferase 7
NCBI Official Synonym Symbols
NCBI Protein Information
protein arginine N-methyltransferase 7; histone-arginine N-methyltransferase PRMT7
UniProt Protein Name
Protein arginine N-methyltransferase 7
UniProt Synonym Protein Names
Histone-arginine N-methyltransferase PRMT7 (EC:2.1.1.125); [Myelin basic protein]-arginine N-methyltransferase PRMT7 (EC:2.1.1.126)
UniProt Entry Name
ANM7_RAT
UniProt Comments for PRMT7
Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo
Catalytic activity: S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone].
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Diseases associated with PRMT7 elisa kit
Organs/Tissues associated with PRMT7 elisa kit
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