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PIAS3 elisa kit :: Rat protein inhibitor of activated STAT, 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9335747 PIAS3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

protein inhibitor of activated STAT, 3 (PIAS3), ELISA Kit

 Also Known As   

Rat E3 SUMO-protein ligase PIAS3, PIAS3 ELISA Kit

 Product Synonym Names    Rat E3 SUMO-protein ligase PIAS3 (PIAS3) ELISA kit; FLJ14651; ZMIZ5; zinc finger; MIZ-type containing 5; protein inhibitor of activated STAT; 3
 Product Gene Name   

PIAS3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O70260
 Species Reactivity    Rat
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PIAS3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PIAS3 purchase    MBS9335747 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the protein inhibitor of activated STAT, 3 (PIAS3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PIAS3. The ELISA analytical biochemical technique of the MBS9335747 kit is based on PIAS3 antibody-PIAS3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PIAS3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PIAS3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PIAS3. It may not necessarily be applicable to this product.
 NCBI GI #    17298668
 NCBI GeneID    83614
 NCBI Accession #    NP_113972.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_031784.2 [Other Products]
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 UniProt Primary Accession #    O70260 [Other Products]
 UniProt Related Accession #    O70260 [Other Products]
 Molecular Weight    68,364 Da
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 NCBI Official Full Name    E3 SUMO-protein ligase PIAS3
 NCBI Official Synonym Full Names    protein inhibitor of activated STAT, 3
 NCBI Official Symbol    Pias3 [Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase PIAS3; KChAP; potassium channel-associated protein; potassium channel regulatory protein KChAP; protein inhibitor of activated STAT protein 3
 UniProt Protein Name    E3 SUMO-protein ligase PIAS3
 UniProt Synonym Protein Names   
KChAP; Potassium channel-associated protein; Protein inhibitor of activated STAT protein 3
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    Pias3 [Similar Products]
 UniProt Entry Name    PIAS3_RAT
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 NCBI Summary for PIAS3    voltage-gated K+ channel binding protein; involved in modulating the expression of Kv2 channels [RGD, Feb 2006]
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 UniProt Comments for PIAS3    PIAS3: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Monomer. Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3- mediated transcriptional activity. Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. By dihydrotestosterone (DHT) in prostate cancer cells. Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. Belongs to the PIAS family.

Protein type: Nuclear receptor co-regulator; SUMO conjugating system; EC 6.3.2.-

Cellular Component: dendrite; cytoplasm; nuclear speck; synapse; nucleus

Molecular Function: protein C-terminus binding; protein binding; potassium channel regulator activity; enzyme binding; zinc ion binding; protein N-terminus binding; SUMO ligase activity; ligase activity

Biological Process: positive regulation of protein sumoylation; protein sumoylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to hormone stimulus; positive regulation of membrane potential
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 Research Articles on PIAS3    1. We have characterized the biological role of a 23-aa domain derived from PIAS3 that induces apoptosis in these cells by inhibiting the transcriptional activity of both MITF and STAT3.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PIAS3 elisa kitDiseases associated with PIAS3 elisa kit
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 TNF-alpha NF-kB Signaling Pathway antibodies  TNF-alpha NF-kB Signaling Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with PIAS3 and Neoplasms
 Liver Diseases Antibodies  >7 publications with PIAS3 and Liver Diseases
 Prostatic Neoplasms Antibodies  >6 publications with PIAS3 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >6 publications with PIAS3 and Breast Neoplasms
 Prostatic Diseases Antibodies  >6 publications with PIAS3 and Prostatic Diseases
 Necrosis Antibodies  >4 publications with PIAS3 and Necrosis
 Hepatitis Antibodies  >3 publications with PIAS3 and Hepatitis
 Liver Neoplasms Antibodies  >2 publications with PIAS3 and Liver Neoplasms
 Adenocarcinoma Antibodies  >2 publications with PIAS3 and Adenocarcinoma
 Uterine Neoplasms Antibodies  >2 publications with PIAS3 and Uterine Neoplasms
Organs/Tissues associated with PIAS3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with PIAS3 and Brain
 Prostate Antibodies  >6 publications with PIAS3 and Prostate
 Heart Antibodies  >5 publications with PIAS3 and Heart
 Adipose Tissue Antibodies  >2 publications with PIAS3 and Adipose Tissue
 Embryonic Tissue Antibodies  >1 publications with PIAS3 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PIAS3 and Kidney
 Pituitary Gland Antibodies  >1 publications with PIAS3 and Pituitary Gland
 Ovary Antibodies  >1 publications with PIAS3 and Ovary
 Connective Tissue Antibodies  >1 publications with PIAS3 and Connective Tissue
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