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PTPN6 elisa kit :: Rat protein tyrosine phosphatase, non-receptor type 6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS931885
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

protein tyrosine phosphatase, non-receptor type 6 (PTPN6), ELISA Kit

★Popular Item★
 Also Known As   

Rat Tyrosine-protein phosphatase non-receptor type 6, PTPN6 ELISA Kit

 Product Synonym Names    Rat Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) ELISA kit; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; protein-tyrosine phosphatase 1C; protein tyrosine phosphatase; non-receptor type 6
 Product Gene Name   

PTPN6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS931885 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for P81718
 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Rat PTPN6. No significant cross-reactivity or interference between Rat PTPN6 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    46.88 pg/ml-3000 pg/ml
 Sensitivity    11.72 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PTPN6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PTPN6 purchase    MBS931885 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the protein tyrosine phosphatase, non-receptor type 6 (PTPN6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 46.88 pg/ml-3000 pg/ml in biological research samples containing PTPN6, with an estimated sensitivity of 11.72 pg/ml. The ELISA analytical biochemical technique of the MBS931885 kit is based on PTPN6 antibody-PTPN6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTPN6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTPN6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PTPN6 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for PTPN6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any PTPN6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PTPN6 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PTPN6 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of PTPN6 elisa kit    PTPN6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS931885. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PTPN6. It may not necessarily be applicable to this product.
 NCBI GI #    16758788
 NCBI GeneID    116689
 NCBI Accession #    NP_446360.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053908.1 [Other Products]
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 UniProt Primary Accession #    P81718 [Other Products]
 UniProt Related Accession #    P81718 [Other Products]
 Molecular Weight    69,578 Da
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 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 6
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 6
 NCBI Official Symbol    Ptpn6 [Similar Products]
 NCBI Official Synonym Symbols   
Ptph6; Shp-1
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 6; SH2 phosphatase 1; protein-tyrosine phosphatase SHP-1
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 6
 UniProt Synonym Protein Names   
Protein-tyrosine phosphatase SHP-1
 Protein Family    Tyrosine-protein phosphatase non-receptor
 UniProt Gene Name    Ptpn6 [Similar Products]
 UniProt Synonym Gene Names    Ptph6 [Similar Products]
 UniProt Entry Name    PTN6_RAT
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 NCBI Summary for PTPN6    plays a role in activation and proliferation of glial cells and astrocytes [RGD, Feb 2006]
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 UniProt Comments for PTPN6    SHP-1: an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Cellular Component: cytoplasm; nucleolus; alpha-beta T cell receptor complex; intracellular; intercellular junction; nucleus

Molecular Function: phosphotyrosine binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; SH3 domain binding; protein kinase binding; natural killer cell lectin-like receptor binding

Biological Process: negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine phosphorylation; negative regulation of MAPKKK cascade; natural killer cell mediated cytotoxicity; positive regulation of cell adhesion mediated by integrin; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation; regulation of release of sequestered calcium ion into cytosol; positive regulation of phosphoinositide 3-kinase cascade; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of B cell receptor signaling pathway; regulation of B cell differentiation; positive regulation of cell proliferation; response to wounding; hemopoietic progenitor cell differentiation; abortive mitotic cell cycle; platelet formation; cell differentiation
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 Research Articles on PTPN6    1. Data indicate that protein tyrosine phosphatases SHP-1, SHP-2 and PTP1B overexpressed during the development of cerulein -induced acute pancreatitis can be modulated by extracellular signal-regulated kinases (ERK1/2) and c-Jun NH2-terminal kinase (JNK).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTPN6 elisa kitPathways associated with PTPN6 elisa kit
 Reference Product  PubMed Publications
 Agtr2 elisa kit  >17 publications with PTPN6 and Agtr2
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-4 Signaling Pathway antibodies  IL-4 Signaling Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
Diseases associated with PTPN6 elisa kitOrgans/Tissues associated with PTPN6 elisa kit
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >124 publications with PTPN6 and Immune System Diseases
 Inflammation Antibodies  >70 publications with PTPN6 and Inflammation
 Death Antibodies  >57 publications with PTPN6 and Death
 Necrosis Antibodies  >42 publications with PTPN6 and Necrosis
 Nervous System Diseases Antibodies  >27 publications with PTPN6 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >26 publications with PTPN6 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >18 publications with PTPN6 and Liver Diseases
 Liver Neoplasms Antibodies  >17 publications with PTPN6 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >16 publications with PTPN6 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >14 publications with PTPN6 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >40 publications with PTPN6 and Brain
 Spleen Antibodies  >34 publications with PTPN6 and Spleen
 Kidney Antibodies  >32 publications with PTPN6 and Kidney
 Lung Antibodies  >25 publications with PTPN6 and Lung
 Heart Antibodies  >16 publications with PTPN6 and Heart
 Thymus Antibodies  >13 publications with PTPN6 and Thymus
 Prostate Antibodies  >10 publications with PTPN6 and Prostate
 Colon Antibodies  >9 publications with PTPN6 and Colon
 Placenta Antibodies  >7 publications with PTPN6 and Placenta
 Connective Tissue Antibodies  >7 publications with PTPN6 and Connective Tissue
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