NP_114456.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,252 Da
NCBI Official Full Name
ralA-binding protein 1
NCBI Official Synonym Full Names
ralA binding protein 1
NCBI Protein Information
ralA-binding protein 1; cytocentrin; DNP-SG ATPase; ral-interacting protein 1; dinitrophenyl S-glutathione ATPase
UniProt Protein Name
RalA-binding protein 1
UniProt Synonym Protein Names
Cytocentrin; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1
UniProt Synonym Gene Names
UniProt Entry Name
RBP1_RAT
NCBI Summary for RALBP1
binds the GTP-bound form of Ras-related GTPase RalA; also interacts with Rho family member CDC42 via a specific Rho-GTPase activating domain [RGD, Feb 2006]
UniProt Comments for RALBP1
RALBP1: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
Protein type: GAPs, Rac/Rho; GAPs
Cellular Component: spindle pole; neuron projection; membrane; integral to membrane; intracellular; cytosol
Molecular Function: protein binding; ATPase activity, coupled to movement of substances; ATPase activity; Rac GTPase binding; Ral GTPase binding; GTPase activator activity
Biological Process: mitosis; regulation of GTPase activity; mitotic spindle organization and biogenesis; negative regulation of smooth muscle cell proliferation; cell division; metabolic process; transport; small GTPase mediated signal transduction; endocytosis; signal transduction; positive regulation of GTPase activity
Research Articles on RALBP1
Precautions
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Pathways associated with RALBP1 elisa kit
Diseases associated with RALBP1 elisa kit
Organs/Tissues associated with RALBP1 elisa kit
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