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SDHA elisa kit :: Rat succinate dehydrogenase complex, subunit A, flavoprotein (Fp) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9336939 SDHA elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), ELISA Kit

 Also Known As   

Rat Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, SDHA ELISA Kit

 Product Synonym Names    Rat Succinate dehydrogenase [ubiquinone] flavoprotein subunit; mitochondrial (SDHA) ELISA kit; FP; SDH1; SDH2; SDHF; succinate dehydrogenase complex flavoprotein subunit; succinate dehydrogenase complex; subunit A; flavoprotein; succinate dehydrogenase complex; subunit A; flavoprotein (Fp)
 Product Gene Name   

SDHA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 3D Structure    ModBase 3D Structure for Q920L2
 Species Reactivity    Rat
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of SDHA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SDHA purchase    MBS9336939 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SDHA. The ELISA analytical biochemical technique of the MBS9336939 kit is based on SDHA antibody-SDHA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SDHA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SDHA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SDHA. It may not necessarily be applicable to this product.
 NCBI GI #    18426858
 NCBI GeneID    157074
 NCBI Accession #    NP_569112.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_130428.1 [Other Products]
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 UniProt Primary Accession #    Q920L2 [Other Products]
 UniProt Related Accession #    Q920L2 [Other Products]
 Molecular Weight    71,615 Da
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 NCBI Official Full Name    succinate dehydrogenase
 NCBI Official Synonym Full Names    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
 NCBI Official Symbol    Sdha [Similar Products]
 NCBI Protein Information    succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; fp; flavoprotein subunit of complex II
 UniProt Protein Name    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
 UniProt Synonym Protein Names   
Flavoprotein subunit of complex II; Fp
 Protein Family    Succinate dehydrogenase
 UniProt Gene Name    Sdha [Similar Products]
 UniProt Synonym Gene Names    Fp [Similar Products]
 UniProt Entry Name    SDHA_RAT
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 NCBI Summary for SDHA    subunit of the mitochondrial succinate hehydrogenase that is involved in the oxidation of succinate; mutation of human homolog is associated with Leigh syndrome [RGD, Feb 2006]
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 UniProt Comments for SDHA    SDHA: is the catalytic subunit of succinate dehydrogenase (SDH) complex II of the mitochondrial electron transport chain. Complex II contains four subunits: the flavoprotein catalytic subunit SDHA, iron-sulfur protein SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interaction with SDH5 is required for FAD attachment. Responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHA cause defective mitochondrial oxidative phosphorylation, giving rise to heterogeneous clinical symptoms ranging from isolated organ dysfunction to multisystem disorder. Acetylation of SDHA may control entry of the substrate into the active site, thus regulating its enzymatic activity. Acetylated SDHA may be a SIRT3 substrate SIRT3 is a mitochondrial NAD(+)-dependent deacetylase. Increased succinate levels as a consequence of SDH deficiency inhibit hypoxia inducible factor-1alpha (HIF-1alpha) prolyl hydroxylases leading to sustained HIF-1alpha expression in tumours. Defects in SDHA cause of Leigh syndrome, a severe disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.

Protein type: Mitochondrial; Carbohydrate Metabolism - citrate (TCA) cycle; Oxidoreductase; EC 1.3.5.1; Tumor suppressor; Energy Metabolism - oxidative phosphorylation
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 Research Articles on SDHA    1. Our results indicate an alteration in the energy metabolism in hippocampus and striatum of infant rats after acute administration of l-tyrosine.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SDHA elisa kitDiseases associated with SDHA elisa kit
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citric Acid Cycle (TCA Cycle) Pathway antibodies  Citric Acid Cycle (TCA Cycle) Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >43 publications with SDHA and Neoplasms
 Nervous System Diseases Antibodies  >14 publications with SDHA and Nervous System Diseases
 Carcinoma Antibodies  >13 publications with SDHA and Carcinoma
 Disease Models, Animal Antibodies  >9 publications with SDHA and Disease Models, Animal
 Brain Diseases Antibodies  >9 publications with SDHA and Brain Diseases
 MITOCHONDRIAL COMPLEX II DEFICIENCY Antibodies  >9 publications with SDHA and MITOCHONDRIAL COMPLEX II DEFICIENCY
 Cardiovascular Diseases Antibodies  >8 publications with SDHA and Cardiovascular Diseases
 Inflammation Antibodies  >5 publications with SDHA and Inflammation
 Adenocarcinoma Antibodies  >4 publications with SDHA and Adenocarcinoma
 Necrosis Antibodies  >4 publications with SDHA and Necrosis
Organs/Tissues associated with SDHA elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with SDHA and Brain
 Muscle Antibodies  >18 publications with SDHA and Muscle
 Liver Antibodies  >13 publications with SDHA and Liver
 Adrenal Gland Antibodies  >11 publications with SDHA and Adrenal Gland
 Heart Antibodies  >11 publications with SDHA and Heart
 Lung Antibodies  >10 publications with SDHA and Lung
 Kidney Antibodies  >9 publications with SDHA and Kidney
 Embryonic Tissue Antibodies  >8 publications with SDHA and Embryonic Tissue
 Colon Antibodies  >6 publications with SDHA and Colon
 Connective Tissue Antibodies  >5 publications with SDHA and Connective Tissue
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