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TLR3 elisa kit :: Rat toll-like receptor 3 (TLR3) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS906354
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

toll-like receptor 3 (TLR3), ELISA Kit

 Also Known As   

Rat toll-like receptor 3, TLR3 ELISA Kit

 Product Synonym Names    Rat toll-like receptor 3 (TLR3) ELISA kit; toll-like receptor 3 (TLR3)
 Product Gene Name   

TLR3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS906354 Testing Data    Testing Data PDF
 OMIM    gene 613002
 3D Structure    ModBase 3D Structure for O15455
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 Species Reactivity    Rat
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Rat TLR3. No significant cross-reactivity or interference between Rat TLR3 and analogues was observed.
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 Assay Type    Sandwich
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of TLR3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TLR3 purchase    MBS906354 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the toll-like receptor 3 (TLR3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TLR3. The ELISA analytical biochemical technique of the MBS906354 kit is based on TLR3 antibody-TLR3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TLR3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TLR3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for TLR3 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TLR3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TLR3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TLR3 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TLR3 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of TLR3 elisa kit    TLR3 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS906354
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NCBI/Uniprot data below describe general gene information for TLR3. It may not necessarily be applicable to this product.
 NCBI GI #    4507531
 NCBI GeneID    7098
 NCBI Accession #    NP_003256.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003265.2 [Other Products]
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 UniProt Primary Accession #    O15455 [Other Products]
 UniProt Secondary Accession #    Q4VAL2; Q504W0; B2RAI7; B7Z7K0; E6Y0F0; E6Y0F1; E9PGH4 [Other Products]
 UniProt Related Accession #    O15455 [Other Products]
 Molecular Weight    103,829 Da
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 NCBI Official Full Name    toll-like receptor 3
 NCBI Official Synonym Full Names    toll-like receptor 3
 NCBI Official Symbol    TLR3 [Similar Products]
 NCBI Official Synonym Symbols   
CD283; IIAE2
[Similar Products]
 NCBI Protein Information    toll-like receptor 3
 UniProt Protein Name    Toll-like receptor 3
 UniProt Synonym Protein Names   
CD_antigen: CD283
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR3 [Similar Products]
 UniProt Entry Name    TLR3_HUMAN
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 NCBI Summary for TLR3    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR3    TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; cell surface; membrane; lysosomal membrane; integral to plasma membrane; cytoplasm; endosome membrane

Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; double-stranded RNA binding; receptor activity

Biological Process: negative regulation of osteoclast differentiation; I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus; MyD88-independent toll-like receptor signaling pathway; male gonad development; activation of NF-kappaB-inducing kinase; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; hyperosmotic response; positive regulation of chemokine biosynthetic process; detection of virus; positive regulation of interferon-beta biosynthetic process; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; microglial cell activation during immune response; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on TLR3    1. The TLR3 rs3775291 T allele has a protective effect against HIV infection among highly exposed HIV seronegative Caucasian intravenous drug users.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TLR3 elisa kitPathways associated with TLR3 elisa kit
 Reference Product  PubMed Publications
 MYD88 elisa kit  >273 publications with TLR3 and MYD88
 CD14 elisa kit  >53 publications with TLR3 and CD14
 TRAF6 elisa kit  >30 publications with TLR3 and TRAF6
 CSK elisa kit  >24 publications with TLR3 and CSK
 Products by Pathway  Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DAI Mediated Induction Of Type I IFNs Pathway antibodies  DAI Mediated Induction Of Type I IFNs Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with TLR3 elisa kitOrgans/Tissues associated with TLR3 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >365 publications with TLR3 and Inflammation
 Necrosis Antibodies  >255 publications with TLR3 and Necrosis
 Neoplasms Antibodies  >133 publications with TLR3 and Neoplasms
 Liver Diseases Antibodies  >81 publications with TLR3 and Liver Diseases
 Nervous System Diseases Antibodies  >80 publications with TLR3 and Nervous System Diseases
 Lung Diseases Antibodies  >65 publications with TLR3 and Lung Diseases
 Asthma Antibodies  >52 publications with TLR3 and Asthma
 Cardiovascular Diseases Antibodies  >51 publications with TLR3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >44 publications with TLR3 and Kidney Diseases
 Sepsis Antibodies  >31 publications with TLR3 and Sepsis
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >125 publications with TLR3 and Lung
 Bone Antibodies  >119 publications with TLR3 and Bone
 Liver Antibodies  >112 publications with TLR3 and Liver
 Kidney Antibodies  >88 publications with TLR3 and Kidney
 Spleen Antibodies  >83 publications with TLR3 and Spleen
 Brain Antibodies  >71 publications with TLR3 and Brain
 Skin Antibodies  >59 publications with TLR3 and Skin
 Intestine Antibodies  >50 publications with TLR3 and Intestine
 Muscle Antibodies  >41 publications with TLR3 and Muscle
 Eye Antibodies  >35 publications with TLR3 and Eye
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