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TSC1 elisa kit :: Rat tuberous sclerosis 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9340411 TSC1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

tuberous sclerosis 1 (TSC1), ELISA Kit

 Also Known As   

Rat Hamartin, TSC1 ELISA Kit

 Product Synonym Names    Rat Hamartin (TSC1) ELISA kit; KIAA0243; LAM; MGC86987; TSC; OTTHUMP00000022439; OTTHUMP00000198378; hamartin; tuberous sclerosis 1 protein; tumor suppressor; tuberous sclerosis 1
 Product Gene Name   

TSC1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for Q9Z136
 Species Reactivity    Rat
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TSC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TSC1 purchase    MBS9340411 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the tuberous sclerosis 1 (TSC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TSC1. The ELISA analytical biochemical technique of the MBS9340411 kit is based on TSC1 antibody-TSC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TSC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TSC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for TSC1. It may not necessarily be applicable to this product.
 NCBI GI #    11177894
 NCBI GeneID    60445
 NCBI Accession #    NP_068626.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021854.1 [Other Products]
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 UniProt Primary Accession #    Q9Z136 [Other Products]
 UniProt Related Accession #    Q9Z136 [Other Products]
 Molecular Weight    129,022 Da
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 NCBI Official Full Name    hamartin
 NCBI Official Synonym Full Names    tuberous sclerosis 1
 NCBI Official Symbol    Tsc1 [Similar Products]
 NCBI Protein Information    hamartin; tuberous sclerosis 1 protein homolog
 UniProt Protein Name    Hamartin
 UniProt Synonym Protein Names   
Tuberous sclerosis 1 protein homolog
 Protein Family    Tuberous sclerosis 1 protein
 UniProt Gene Name    Tsc1 [Similar Products]
 UniProt Entry Name    TSC1_RAT
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 UniProt Comments for TSC1    TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Cellular Component: TSC1-TSC2 complex; growth cone; protein complex; cytoskeleton; membrane; intracellular membrane-bound organelle; lamellipodium; cytoplasm; plasma membrane; actin filament; cell cortex; cytosol

Molecular Function: chaperone binding; GTPase activating protein binding; protein N-terminus binding; GTPase regulator activity

Biological Process: myelination; protein heterooligomerization; regulation of cell-matrix adhesion; regulation of cell cycle; cell-matrix adhesion; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; regulation of phosphoprotein phosphatase activity; cardiac muscle cell differentiation; response to insulin stimulus; regulation of translation; negative regulation of cell proliferation; positive regulation of focal adhesion formation; cell projection organization and biogenesis; synapse organization and biogenesis; kidney development; potassium ion transport; nervous system development; negative regulation of TOR signaling pathway; protein stabilization; hippocampus development; rRNA export from nucleus; regulation of actin cytoskeleton organization and biogenesis; negative regulation of translation; regulation of stress fiber formation; glucose import; neural tube closure; regulation of focal adhesion formation; cerebral cortex development; regulation of protein kinase activity
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 Research Articles on TSC1    1. TSC1 is selectively induced by ischemia in hippocampal CA3 neurons; in CA1 neurons, TSC1 was unaffected by ischemia but was upregulated by ischemic preconditioning preceding ischemia; overexpression of TSC1 increased resistance to oxygen glucose deprivation by inducing productive autophagy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TSC1 elisa kitDiseases associated with TSC1 elisa kit
 Products by Pathway  Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 Inhibition Of TSC Complex Formation By PKB Pathway antibodies  Inhibition Of TSC Complex Formation By PKB Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 PI3K Cascade Pathway antibodies  PI3K Cascade Pathway Diagram
 PKB-mediated Events Pathway antibodies  PKB-mediated Events Pathway Diagram
 Disease Name  Pubmed Publications
 Tuberous Sclerosis Antibodies  >769 publications with TSC1 and Tuberous Sclerosis
 Neoplasms Antibodies  >561 publications with TSC1 and Neoplasms
 Epilepsy Antibodies  >120 publications with TSC1 and Epilepsy
 Brain Diseases Antibodies  >98 publications with TSC1 and Brain Diseases
 Kidney Diseases Antibodies  >76 publications with TSC1 and Kidney Diseases
 Lymphangioleiomyomatosis Antibodies  >72 publications with TSC1 and Lymphangioleiomyomatosis
 Disease Models, Animal Antibodies  >63 publications with TSC1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >43 publications with TSC1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >33 publications with TSC1 and Adenocarcinoma
 Carcinoma, Renal Cell Antibodies  >32 publications with TSC1 and Carcinoma, Renal Cell
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