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HPGD elisa kit :: Sheep 15-hydroxyprostaglandin dehydrogenase (NAD+] (HPGD) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7234486 HPGD elisa kit
Unit / Price
48-Strip-Wells  /  $455 +1 FREE 8GB USB
96-Strip-Wells  /  $660 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

15-hydroxyprostaglandin dehydrogenase (NAD+] (HPGD), ELISA Kit

 Also Known As   

Sheep 15-hydroxyprostaglandin dehydrogenase (NAD+] (HPGD) ELISA Kit

 Product Gene Name   

HPGD elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    601688
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 Species Reactivity    Sheep
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HPGD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HPGD purchase    MBS7234486 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 15-hydroxyprostaglandin dehydrogenase (NAD+] (HPGD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HPGD. The ELISA analytical biochemical technique of the MBS7234486 kit is based on HPGD antibody-HPGD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HPGD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HPGD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HPGD. It may not necessarily be applicable to this product.
 NCBI GI #    2047313
 NCBI GeneID    3248
 NCBI Accession #    AAB53034.1 [Other Products]
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 UniProt Secondary Accession #    O00749; Q06F08; Q12998; B4DTA4; B4DU74; B4DV57; D3DP43; E7EV11 [Other Products]
 UniProt Related Accession #    P15428 [Other Products]
 Molecular Weight    21,526 Da [Similar Products]
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 NCBI Official Full Name    15-hydroxyprostaglandin dehydrogenase
 NCBI Official Synonym Full Names    hydroxyprostaglandin dehydrogenase 15-(NAD)
 NCBI Official Symbol    HPGD [Similar Products]
 NCBI Official Synonym Symbols   
PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1
[Similar Products]
 NCBI Protein Information    15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; prostaglandin dehydrogenase 1; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 36C, member 1
 UniProt Protein Name    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
 UniProt Synonym Protein Names   
Prostaglandin dehydrogenase 1
 Protein Family    15-hydroxyprostaglandin dehydrogenase
 UniProt Gene Name    HPGD [Similar Products]
 UniProt Synonym Gene Names    PGDH1; 15-PGDH [Similar Products]
 UniProt Entry Name    PGDH_HUMAN
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 NCBI Summary for HPGD    This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for HPGD    HPGD: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 1 (PHOAR1). A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Defects in HPGD are the cause of cranioosteoarthropathy (COA). A form of osterarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC); also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.141; Tumor suppressor; Oxidoreductase

Chromosomal Location of Human Ortholog: 4q34-q35

Cellular Component: basolateral plasma membrane; cytosol

Molecular Function: protein homodimerization activity; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; catalytic activity; NAD binding; prostaglandin E receptor activity

Biological Process: ovulation; lipoxygenase pathway; transforming growth factor beta receptor signaling pathway; cyclooxygenase pathway; arachidonic acid metabolic process; parturition; female pregnancy; prostaglandin metabolic process; negative regulation of cell cycle

Disease: Digital Clubbing, Isolated Congenital; Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
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 Research Articles on HPGD    1. 15-PGDH is downregulated in human hepatoma cells with a high COX-2 expression, in chemical and genetic murine models of hepatocellular carcinoma (HCC) and in human HCC biopsies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HPGD elisa kitPathways associated with HPGD elisa kit
 Reference Product  PubMed Publications
 PTGS2 elisa kit  >14 publications with HPGD and PTGS2
 SLCO2A1 elisa kit  >13 publications with HPGD and SLCO2A1
 PTGES elisa kit  >7 publications with HPGD and PTGES
 PTGS1 elisa kit  >5 publications with HPGD and PTGS1
 IL1B elisa kit  >1 publications with HPGD and IL1B
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Synthesis Of Lipoxins (LX) Pathway antibodies  Synthesis Of Lipoxins (LX) Pathway Diagram
 Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway antibodies  Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with HPGD elisa kitOrgans/Tissues associated with HPGD elisa kit
 Disease Name  Pubmed Publications
 Osteoarthropathy, Primary Hypertrophic Antibodies  >15 publications with HPGD and Osteoarthropathy, Primary Hypertrophic
 HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL RECESSIVE, 1 Antibodies  >15 publications with HPGD and HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL RECESSIVE, 1
 Inflammation Antibodies  >9 publications with HPGD and Inflammation
 Breast Neoplasms Antibodies  >3 publications with HPGD and Breast Neoplasms
 Fetal Growth Retardation Antibodies  >2 publications with HPGD and Fetal Growth Retardation
 Fibrosis Antibodies  >2 publications with HPGD and Fibrosis
 Prostatic Neoplasms Antibodies  >2 publications with HPGD and Prostatic Neoplasms
 Arthritis, Rheumatoid Antibodies  >1 publications with HPGD and Arthritis, Rheumatoid
 Neoplasms, Experimental Antibodies  >1 publications with HPGD and Neoplasms, Experimental
 Hypertrophy Antibodies  >1 publications with HPGD and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >7 publications with HPGD and Uterus
 Placenta Antibodies  >5 publications with HPGD and Placenta
 Embryonic Tissue Antibodies  >4 publications with HPGD and Embryonic Tissue
 Prostate Antibodies  >4 publications with HPGD and Prostate
 Lung Antibodies  >4 publications with HPGD and Lung
 Skin Antibodies  >3 publications with HPGD and Skin
 Heart Antibodies  >3 publications with HPGD and Heart
 Muscle Antibodies  >2 publications with HPGD and Muscle
 Stomach Antibodies  >2 publications with HPGD and Stomach
 Intestine Antibodies  >2 publications with HPGD and Intestine
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