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HMGCS elisa kit :: Sheep 3-Hydroxy-3-methylglutaryl-Coenzyme A Synthase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS753476 HMGCS elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-Hydroxy-3-methylglutaryl-Coenzyme A Synthase (HMGCS), ELISA Kit

 Also Known As   

Sheep 3-Hydroxy-3-methylglutaryl-Coenzyme A Synthase ELISA Kit

 Product Gene Name   

HMGCS elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    142940
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 Species Reactivity    Sheep
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HMGCS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HMGCS purchase    MBS753476 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 3-Hydroxy-3-methylglutaryl-Coenzyme A Synthase (HMGCS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HMGCS. The ELISA analytical biochemical technique of the MBS753476 kit is based on HMGCS antibody-HMGCS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HMGCS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HMGCS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HMGCS. It may not necessarily be applicable to this product.
 NCBI GI #    148298764
 NCBI GeneID    3157
 NCBI Accession #    NP_002121.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002130.7 [Other Products]
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 UniProt Secondary Accession #    B2RDL8 [Other Products]
 UniProt Related Accession #    Q01581 [Other Products]
 Molecular Weight    57,294 Da
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 NCBI Official Full Name    hydroxymethylglutaryl-CoA synthase, cytoplasmic
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
 NCBI Official Symbol    HMGCS1 [Similar Products]
 NCBI Official Synonym Symbols   
HMGCS
[Similar Products]
 NCBI Protein Information    hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
 UniProt Protein Name    Hydroxymethylglutaryl-CoA synthase, cytoplasmic
 UniProt Synonym Protein Names   
3-hydroxy-3-methylglutaryl coenzyme A synthase
 UniProt Gene Name    HMGCS1 [Similar Products]
 UniProt Synonym Gene Names    HMGCS; HMG-CoA synthase [Similar Products]
 UniProt Entry Name    HMCS1_HUMAN
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 UniProt Comments for HMGCS    HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.

Protein type: Lipid Metabolism - synthesis and degradation of ketone bodies; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Transferase; EC 2.3.3.10; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 5p14-p13

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein homodimerization activity; hydroxymethylglutaryl-CoA synthase activity; organic acid binding; drug binding; isomerase activity

Biological Process: response to drug; response to purine; isoprenoid biosynthetic process; male gonad development; cellular lipid metabolic process; liver development; cholesterol biosynthetic process; response to low light intensity; response to vitamin E; response to tellurium ion; response to lipoprotein stimulus; lipid metabolic process; brain development
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 Research Articles on HMGCS    1. The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HMGCS elisa kitPathways associated with HMGCS elisa kit
 Reference Product  PubMed Publications
 PPARA elisa kit  >2 publications with HMGCS and PPARA
 SREBF2 elisa kit  >2 publications with HMGCS and SREBF2
 EHHADH elisa kit  >1 publications with HMGCS and EHHADH
 HMGCL elisa kit  >1 publications with HMGCS and HMGCL
 ACAT2 elisa kit  >1 publications with HMGCS and ACAT2
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Diseases associated with HMGCS elisa kitOrgans/Tissues associated with HMGCS elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >6 publications with HMGCS and Liver Diseases
 Fatty Liver Antibodies  >4 publications with HMGCS and Fatty Liver
 Mental Disorders Antibodies  >3 publications with HMGCS and Mental Disorders
 Liver Neoplasms Antibodies  >3 publications with HMGCS and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with HMGCS and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >3 publications with HMGCS and Disease Models, Animal
 Inflammation Antibodies  >3 publications with HMGCS and Inflammation
 Abnormalities, Drug-Induced Antibodies  >2 publications with HMGCS and Abnormalities, Drug-Induced
 Hepatitis Antibodies  >2 publications with HMGCS and Hepatitis
 Cardiovascular Diseases Antibodies  >2 publications with HMGCS and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >17 publications with HMGCS and Liver
 Blood Antibodies  >8 publications with HMGCS and Blood
 Brain Antibodies  >3 publications with HMGCS and Brain
 Bone Antibodies  >2 publications with HMGCS and Bone
 Ovary Antibodies  >2 publications with HMGCS and Ovary
 Nerve Antibodies  >2 publications with HMGCS and Nerve
 Connective Tissue Antibodies  >2 publications with HMGCS and Connective Tissue
 Kidney Antibodies  >1 publications with HMGCS and Kidney
 Testis Antibodies  >1 publications with HMGCS and Testis
 Skin Antibodies  >1 publications with HMGCS and Skin
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