NP_954635.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
NCBI Official Full Name
5-aminolevulinate synthase, nonspecific, mitochondrial
NCBI Official Synonym Full Names
aminolevulinate, delta-, synthase 1
NCBI Protein Information
5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1
UniProt Protein Name
5-aminolevulinate synthase, nonspecific, mitochondrial
UniProt Synonym Protein Names
5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1
UniProt Synonym Gene Names
UniProt Entry Name
HEM1_HUMAN
NCBI Summary for ALAS1
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
UniProt Comments for ALAS1
ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Protein type: Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 2.3.1.37; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonine
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm
Molecular Function: 5-aminolevulinate synthase activity; pyridoxal phosphate binding
Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process
Research Articles on ALAS1
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Products associated with ALAS1 elisa kit
Pathways associated with ALAS1 elisa kit
Diseases associated with ALAS1 elisa kit
Organs/Tissues associated with ALAS1 elisa kit
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