NP_001074288.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
206,532 Da
NCBI Official Full Name
AT-rich interactive domain-containing protein 1A
NCBI Official Synonym Full Names
AT rich interactive domain 1A (SWI-like)
NCBI Official Synonym Symbols
Osa1; BAF250a; Smarcf1; 1110030E03Rik [Similar Products]
NCBI Protein Information
AT-rich interactive domain-containing protein 1A; BAF250; Swi1 like; osa homolog 1; SWI-like protein; BRG1-associated factor 250; BRG1-associated factor 250a; SWI-SNF complex protein p270; SWI/SNF complex protein p270; ARID domain-containing protein 1A; AT rich interactive domain 1A (Swi1 like); SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1
UniProt Protein Name
AT-rich interactive domain-containing protein 1A
UniProt Synonym Protein Names
BRG1-associated factor 250; BAF250; BRG1-associated factor 250a; BAF250A; Osa homolog 1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
UniProt Synonym Gene Names
Baf250; Baf250a; Osa1; Smarcf1; ARID domain-containing protein 1A; BAF250; BAF250A [Similar Products]
UniProt Entry Name
ARI1A_MOUSE
UniProt Comments for ARID1A
ARID1A: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Defects in ARID1A are the cause of mental retardation autosomal dominant type 14 (MRD14). A disease characterized by multiple congenital anomalies and mental retardation. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRD14 patients manifest developmental delay, abnormal corpus callosum, absent/hypoplastic fifth finger/toenails, sparse scalp hair, long eyelashes, and a coarse facial appearance with wide mouth, thick lips, and abnormal ears. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator; DNA-binding
Cellular Component: nucleoplasm; SWI/SNF complex; nuclear chromatin; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; nucleosome binding
Biological Process: nervous system development; establishment and/or maintenance of chromatin architecture; estrogen receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cardiac muscle cell differentiation; chromatin remodeling; nucleosome disassembly; regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; neural tube closure; forebrain development; androgen receptor signaling pathway; maintenance of chromatin silencing; ATP-dependent chromatin remodeling
Research Articles on ARID1A
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Products associated with ARID1A elisa kit
Pathways associated with ARID1A elisa kit
Diseases associated with ARID1A elisa kit
Organs/Tissues associated with ARID1A elisa kit
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