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KCNJ11 elisa kit :: Sheep ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7211640 KCNJ11 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $675 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,925 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,490 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP-sensitive inward rectifier potassium channel 11 (KCNJ11), ELISA Kit

 Also Known As   

Sheep ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) ELISA Kit

 Product Gene Name   

KCNJ11 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    610582
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 Species Reactivity    Sheep
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KCNJ11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KCNJ11 purchase    MBS7211640 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATP-sensitive inward rectifier potassium channel 11 (KCNJ11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNJ11. The ELISA analytical biochemical technique of the MBS7211640 kit is based on KCNJ11 antibody-KCNJ11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNJ11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNJ11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for KCNJ11 elisa kit    Signal Transduction
NCBI/Uniprot data below describe general gene information for KCNJ11. It may not necessarily be applicable to this product.
 NCBI GI #    62388888
 NCBI GeneID    3767
 NCBI Accession #    NP_000516.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000525.3 [Other Products]
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 UniProt Secondary Accession #    Q2M1H7; Q58EX3; Q8IW96; B4DWI4; E9PNK0 [Other Products]
 UniProt Related Accession #    Q14654 [Other Products]
 Molecular Weight    33,263 Da
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 11 isoform 1
 NCBI Official Synonym Full Names    potassium inwardly-rectifying channel, subfamily J, member 11
 NCBI Official Symbol    KCNJ11 [Similar Products]
 NCBI Official Synonym Symbols   
BIR; HHF2; PHHI; IKATP; TNDM3; KIR6.2
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; potassium channel inwardly rectifing subfamily J member 11; potassium channel, inwardly rectifying subfamily J member 11
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 11
 UniProt Synonym Protein Names   
IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ11 [Similar Products]
 UniProt Entry Name    KCJ11_HUMAN
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 NCBI Summary for KCNJ11    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for KCNJ11    Kir6.2: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2); also known as persistent hyperinsulinemic hypoglycemia of infancy (PPHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. Defects in KCNJ11 are a cause of diabetes mellitus permanent neonatal (PNDM). PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3 (TNDM3). Neonatal diabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. In about half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have a permanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetes type 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestational diabetes or adult-onset diabetes described. Defects in KCNJ11 may contribute to non-insulin- dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type 2. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: voltage-gated potassium channel complex; mitochondrion; cell soma; endoplasmic reticulum; integral to plasma membrane; T-tubule; plasma membrane; ATP-sensitive potassium channel complex; nuclear envelope; axolemma; cytosol; myelin sheath; endosome

Molecular Function: potassium ion binding; protein C-terminus binding; voltage-gated potassium channel activity; G-protein activated inward rectifier potassium channel activity; heat shock protein binding; ATP-activated inward rectifier potassium channel activity; ankyrin binding; ATP binding

Biological Process: response to drug; synaptic transmission; regulation of membrane potential; potassium ion import; energy reserve metabolic process; glucose metabolic process; response to testosterone stimulus; regulation of insulin secretion; response to estradiol stimulus; response to ATP; neurological system process; negative regulation of insulin secretion

Disease: Maturity-onset Diabetes Of The Young, Type 13; Hyperinsulinemic Hypoglycemia, Familial, 2; Diabetes Mellitus, Transient Neonatal, 3; Diabetes Mellitus, Permanent Neonatal; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on KCNJ11    1. KCNJ11 mutations in familial early-onset type 2 diabetes mellitus may help in understanding the molecular aetiology and in providing more personalised treatment for these specific forms of diabetes in Chinese and other Asian patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNJ11 elisa kitPathways associated with KCNJ11 elisa kit
 Reference Product  PubMed Publications
 ABCC8 elisa kit  >242 publications with KCNJ11 and ABCC8
 ABCC9 elisa kit  >12 publications with KCNJ11 and ABCC9
 KCNJ8 elisa kit  >12 publications with KCNJ11 and KCNJ8
 ISL1 elisa kit  >3 publications with KCNJ11 and ISL1
 CACNA1C elisa kit  >2 publications with KCNJ11 and CACNA1C
 Products by Pathway  Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Type II Diabetes Mellitus Pathway antibodies  Type II Diabetes Mellitus Pathway Diagram
Diseases associated with KCNJ11 elisa kitOrgans/Tissues associated with KCNJ11 elisa kit
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >154 publications with KCNJ11 and Diabetes Mellitus, Type 2
 Hypoglycemia Antibodies  >118 publications with KCNJ11 and Hypoglycemia
 Congenital Hyperinsulinism Antibodies  >100 publications with KCNJ11 and Congenital Hyperinsulinism
 Diabetes Mellitus, Type 1 Antibodies  >70 publications with KCNJ11 and Diabetes Mellitus, Type 1
 Hyperglycemia Antibodies  >51 publications with KCNJ11 and Hyperglycemia
 Insulin Resistance Antibodies  >41 publications with KCNJ11 and Insulin Resistance
 Cardiovascular Diseases Antibodies  >28 publications with KCNJ11 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >17 publications with KCNJ11 and Vascular Diseases
 Diabetes Mellitus, Transient Neonatal, 3 Antibodies  >15 publications with KCNJ11 and Diabetes Mellitus, Transient Neonatal, 3
 Hypertension Antibodies  >14 publications with KCNJ11 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >91 publications with KCNJ11 and Pancreas
 Muscle Antibodies  >34 publications with KCNJ11 and Muscle
 Brain Antibodies  >26 publications with KCNJ11 and Brain
 Liver Antibodies  >11 publications with KCNJ11 and Liver
 Kidney Antibodies  >9 publications with KCNJ11 and Kidney
 Nerve Antibodies  >7 publications with KCNJ11 and Nerve
 Intestine Antibodies  >5 publications with KCNJ11 and Intestine
 Ovary Antibodies  >4 publications with KCNJ11 and Ovary
 Thyroid Antibodies  >3 publications with KCNJ11 and Thyroid
 Eye Antibodies  >2 publications with KCNJ11 and Eye
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