CAG33359.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,599 Da
NCBI Official Full Name
ACP5
NCBI Official Synonym Full Names
acid phosphatase 5, tartrate resistant
NCBI Protein Information
tartrate-resistant acid phosphatase type 5; TrATPase; tartrate-resistant acid ATPase
UniProt Protein Name
Tartrate-resistant acid phosphatase type 5
UniProt Synonym Protein Names
Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase
UniProt Synonym Gene Names
UniProt Entry Name
PPA5_HUMAN
NCBI Summary for ACP5
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
UniProt Comments for ACP5
ACP5: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI). A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease. Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
Protein type: Phosphatase; Motility/polarity/chemotaxis; EC 3.1.3.2; Cofactor and Vitamin Metabolism - riboflavin
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: lysosome; integral to membrane; cytosol
Molecular Function: acid phosphatase activity; ferric iron binding; ferrous iron binding
Biological Process: negative regulation of interleukin-12 production; vitamin metabolic process; negative regulation of nitric oxide biosynthetic process; response to lipopolysaccharide; negative regulation of superoxide release; negative regulation of tumor necrosis factor production; negative regulation of interleukin-1 beta production; riboflavin metabolic process; defense response to Gram-positive bacterium; dephosphorylation; response to cytokine stimulus; negative regulation of inflammatory response; water-soluble vitamin metabolic process; bone resorption
Disease: Spondyloenchondrodysplasia With Immune Dysregulation
Research Articles on ACP5
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Products associated with ACP5 elisa kit
Pathways associated with ACP5 elisa kit
Diseases associated with ACP5 elisa kit
Organs/Tissues associated with ACP5 elisa kit
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