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ALK1 elisa kit :: Sheep Activin Receptor Like Kinase 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS006027 ALK1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activin Receptor Like Kinase 1 (ALK1), ELISA Kit

 Also Known As   

Sheep Activin Receptor Like Kinase 1 ELISA Kit

 Product Gene Name   

ALK1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    608981
 3D Structure    ModBase 3D Structure for Q8NER5
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 Species Reactivity    Sheep
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ALK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ALK1 purchase    MBS006027 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activin Receptor Like Kinase 1 (ALK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ALK1. The ELISA analytical biochemical technique of the MBS006027 kit is based on ALK1 antibody-ALK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ALK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ALK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ALK1. It may not necessarily be applicable to this product.
 NCBI GI #    161333833
 NCBI GeneID    130399
 NCBI Accession #    NP_660302.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_145259.2 [Other Products]
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 UniProt Primary Accession #    Q8NER5 [Other Products]
 UniProt Secondary Accession #    Q4ZFZ8; Q86UL1; Q86UL2; Q8TBG2 [Other Products]
 UniProt Related Accession #    Q8NER5 [Other Products]
 Molecular Weight    54,871 Da
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 NCBI Official Full Name    activin receptor type-1C isoform 1
 NCBI Official Synonym Full Names    activin A receptor, type IC
 NCBI Official Symbol    ACVR1C [Similar Products]
 NCBI Official Synonym Symbols   
ALK7; ACVRLK7
[Similar Products]
 NCBI Protein Information    activin receptor type-1C; ALK-7; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7
 UniProt Protein Name    Activin receptor type-1C
 UniProt Synonym Protein Names   
Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7
 Protein Family    Serine/threonine-protein kinase haspin
 UniProt Gene Name    ACVR1C [Similar Products]
 UniProt Synonym Gene Names    ALK7; ACTR-IC; ALK-7 [Similar Products]
 UniProt Entry Name    ACV1C_HUMAN
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 NCBI Summary for ALK1    ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for ALK1    ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Membrane protein, integral; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: plasma membrane; activin receptor complex

Molecular Function: transforming growth factor beta receptor activity; activin receptor activity, type I; growth factor binding; metal ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; response to insulin stimulus; negative regulation of insulin secretion
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 Research Articles on ALK1    1. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ALK1 elisa kitPathways associated with ALK1 elisa kit
 Reference Product  PubMed Publications
 NODAL elisa kit  >26 publications with ALK1 and NODAL
 SMAD2 elisa kit  >21 publications with ALK1 and SMAD2
 GDF3 elisa kit  >5 publications with ALK1 and GDF3
 ACVR1 elisa kit  >4 publications with ALK1 and ACVR1
 INHBB elisa kit  >3 publications with ALK1 and INHBB
 TDGF1 elisa kit  >3 publications with ALK1 and TDGF1
 CCNG2 elisa kit  >2 publications with ALK1 and CCNG2
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with ALK1 elisa kitOrgans/Tissues associated with ALK1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with ALK1 and Neoplasms
 Disease Models, Animal Antibodies  >3 publications with ALK1 and Disease Models, Animal
 Fibrosis Antibodies  >3 publications with ALK1 and Fibrosis
 Liver Diseases Antibodies  >2 publications with ALK1 and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with ALK1 and Breast Neoplasms
 Skin Diseases Antibodies  >2 publications with ALK1 and Skin Diseases
 Kidney Diseases Antibodies  >2 publications with ALK1 and Kidney Diseases
 Chromosome Aberrations Antibodies  >1 publications with ALK1 and Chromosome Aberrations
 Cell Transformation, Neoplastic Antibodies  >1 publications with ALK1 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >1 publications with ALK1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ALK1 and Brain
 Adipose Tissue Antibodies  >4 publications with ALK1 and Adipose Tissue
 Lung Antibodies  >2 publications with ALK1 and Lung
 Spleen Antibodies  >1 publications with ALK1 and Spleen
 Intestine Antibodies  >1 publications with ALK1 and Intestine
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