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SNCA elisa kit :: Sheep Alpha Synuclein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS008732 SNCA elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Alpha Synuclein (SNCA), ELISA Kit

 Also Known As   

Sheep Alpha Synuclein ELISA Kit

 Product Gene Name   

SNCA elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 4; NC_000004.11 (90645250..90759447, complement). Location: 4q21
 OMIM    127750
 3D Structure    ModBase 3D Structure for P37840
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 Species Reactivity    Sheep
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of SNCA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SNCA purchase    MBS008732 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Alpha Synuclein (SNCA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SNCA. The ELISA analytical biochemical technique of the MBS008732 kit is based on SNCA antibody-SNCA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SNCA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SNCA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    49456267
 NCBI GeneID    6622
 NCBI Accession #    CAG46454.1 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    14,460 Da
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 NCBI Official Full Name    SNCA
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for SNCA    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; rough endoplasmic reticulum; lysosome; fibril; extracellular region; terminal button; cell cortex; inclusion body; cytosol; mitochondrial respiratory chain complex I; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; cell junction; nucleus

Molecular Function: protein domain specific binding; identical protein binding; histone binding; zinc ion binding; kinesin binding; microtubule binding; ferrous iron binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; Hsp70 protein binding; oxidoreductase activity; calcium ion binding; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; tau protein binding; fatty acid binding; alpha-tubulin binding

Biological Process: regulation of acyl-CoA biosynthetic process; positive regulation of apoptosis; adult locomotory behavior; positive regulation of endocytosis; response to lipopolysaccharide; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of monooxygenase activity; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of macrophage activation; regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

Disease: Parkinson Disease 4, Autosomal Dominant; Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant
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 Research Articles on SNCA    1. SNCA genotype was associated with the degree of fMRI blood oxygenation level-dependent (BOLD) response in heavy drinkers during exposure to the taste of alcohol versus a control taste
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNCA elisa kitPathways associated with SNCA elisa kit
 Reference Product  PubMed Publications
 LRRK2 elisa kit  >113 publications with SNCA and LRRK2
 PARK7 elisa kit  >49 publications with SNCA and PARK7
 SNCAIP elisa kit  >31 publications with SNCA and SNCAIP
 PARK2 elisa kit  >30 publications with SNCA and PARK2
 SLC6A3 elisa kit  >12 publications with SNCA and SLC6A3
 BAD elisa kit  >3 publications with SNCA and BAD
 FYN elisa kit  >2 publications with SNCA and FYN
 STUB1 elisa kit  >1 publications with SNCA and STUB1
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with SNCA elisa kitOrgans/Tissues associated with SNCA elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1054 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1034 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1021 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >901 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >833 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >766 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >271 publications with SNCA and Lewy Body Disease
 Nerve Degeneration Antibodies  >162 publications with SNCA and Nerve Degeneration
 Disease Models, Animal Antibodies  >127 publications with SNCA and Disease Models, Animal
 Drug Toxicity Antibodies  >71 publications with SNCA and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >989 publications with SNCA and Nerve
 Brain Antibodies  >723 publications with SNCA and Brain
 Blood Antibodies  >54 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >19 publications with SNCA and Kidney
 Heart Antibodies  >9 publications with SNCA and Heart
 Eye Antibodies  >9 publications with SNCA and Eye
 Skin Antibodies  >6 publications with SNCA and Skin
 Bone Antibodies  >6 publications with SNCA and Bone
 Liver Antibodies  >6 publications with SNCA and Liver
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