P37088.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,234 Da
NCBI Official Full Name
Amiloride-sensitive sodium channel subunit alpha
NCBI Official Synonym Full Names
sodium channel, non-voltage-gated 1 alpha subunit
NCBI Official Synonym Symbols
BESC2; ENaCa; SCNEA; SCNN1; ENaCalpha [Similar Products]
NCBI Protein Information
amiloride-sensitive sodium channel subunit alpha; alpha-ENaC; alpha-NaCH; alpha ENaC-2; epithelial Na(+) channel subunit alpha; sodium channel, nonvoltage-gated 1 alpha; nasal epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; amiloride-sensitive epithelial sodium channel alpha subunit
UniProt Protein Name
Amiloride-sensitive sodium channel subunit alpha
UniProt Synonym Protein Names
Alpha-NaCH; Epithelial Na(+) channel subunit alpha; Alpha-ENaC; ENaCA; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA
UniProt Synonym Gene Names
UniProt Entry Name
SCNNA_HUMAN
NCBI Summary for SCNN1A
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
UniProt Comments for SCNN1A
ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Membrane protein, multi-pass; Channel, sodium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cortical actin cytoskeleton; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol; external side of plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; protein binding; WW domain binding; actin binding
Biological Process: sensory perception of taste; response to stimulus; sodium ion transport; sodium ion homeostasis; multicellular organismal water homeostasis; excretion; transmembrane transport
Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 2; Pseudohypoaldosteronism, Type I, Autosomal Recessive
Research Articles on SCNN1A
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Organs/Tissues associated with SCNN1A elisa kit
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