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BCL3 elisa kit :: Sheep B-Cell Cll/Lymphoma 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS039577 BCL3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

B-Cell Cll/Lymphoma 3 (BCL3), ELISA Kit

 Also Known As   

Sheep B-Cell Cll/Lymphoma 3 ELISA Kit

 Product Gene Name   

BCL3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 19; NC_000019.9 (45251978..45263301). Location: 19q13.1-q13.2
 OMIM    109560
 3D Structure    ModBase 3D Structure for P20749
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 Species Reactivity    Sheep
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of BCL3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for BCL3 purchase    MBS039577 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the B-Cell Cll/Lymphoma 3 (BCL3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BCL3. The ELISA analytical biochemical technique of the MBS039577 kit is based on BCL3 antibody-BCL3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BCL3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BCL3. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for BCL3. It may not necessarily be applicable to this product.
 NCBI GI #    164664508
 NCBI GeneID    602
 NCBI Accession #    NP_005169.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005178.4 [Other Products]
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 UniProt Primary Accession #    P20749 [Other Products]
 UniProt Related Accession #    P20749 [Other Products]
 Molecular Weight    47,584 Da
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 NCBI Official Full Name    B-cell lymphoma 3 protein
 NCBI Official Synonym Full Names    B-cell CLL/lymphoma 3
 NCBI Official Symbol    BCL3 [Similar Products]
 NCBI Official Synonym Symbols   
BCL4; D19S37
[Similar Products]
 NCBI Protein Information    B-cell lymphoma 3 protein; BCL-3; proto-oncogene BCL3; B-cell leukemia/lymphoma 3; B-cell lymphoma 3-encoded protein; chronic lymphatic leukemia protein
 UniProt Protein Name    B-cell lymphoma 3 protein
 UniProt Synonym Protein Names   
Proto-oncogene BCL3
 Protein Family    B-cell lymphoma 3 protein
 UniProt Gene Name    BCL3 [Similar Products]
 UniProt Synonym Gene Names    BCL4; D19S37; BCL-3 [Similar Products]
 UniProt Entry Name    BCL3_HUMAN
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 NCBI Summary for BCL3    This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BCL3    Function: Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation

By similarity. Ref.4

Subunit structure: Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2, COPS5 and PIR. Interacts with CYLD

By similarity. Ref.4 Ref.5 Ref.6 Ref.7

Subcellular location: Nucleus. Cytoplasm

By similarity. Cytoplasm › perinuclear region

By similarity. Note: Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation

By similarity.

Post-translational modification: Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation

By similarity.Activated by phosphorylation.

Involvement in disease: A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.

Sequence similarities: Contains 7 ANK repeats.

Caution: It is uncertain whether Met-1 or Met-9 is the initiator.

Sequence caution: The sequence AAA51815.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA51816.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH64993.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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 Research Articles on BCL3    1. using Bcl-3 knockdown in prostate cancer cells, identified the inhibitor of DNA-binding (Id) family of helix-loop-helix proteins as potential Bcl-3-regulated genes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BCL3 elisa kitPathways associated with BCL3 elisa kit
 Reference Product  PubMed Publications
 JUN elisa kit  >20 publications with BCL3 and JUN
 NFKB2 elisa kit  >11 publications with BCL3 and NFKB2
 RELB elisa kit  >8 publications with BCL3 and RELB
 STAT3 elisa kit  >6 publications with BCL3 and STAT3
 RELA elisa kit  >4 publications with BCL3 and RELA
 NFKB1 elisa kit  >4 publications with BCL3 and NFKB1
 TBP elisa kit  >1 publications with BCL3 and TBP
 Products by Pathway  Pathway Diagram
 Atypical NF-kappaB Pathway antibodies  Atypical NF-kappaB Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with BCL3 elisa kitOrgans/Tissues associated with BCL3 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >68 publications with BCL3 and Neoplasms
 Nervous System Diseases Antibodies  >9 publications with BCL3 and Nervous System Diseases
 Necrosis Antibodies  >9 publications with BCL3 and Necrosis
 Inflammation Antibodies  >8 publications with BCL3 and Inflammation
 Breast Neoplasms Antibodies  >5 publications with BCL3 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with BCL3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >5 publications with BCL3 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >5 publications with BCL3 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >4 publications with BCL3 and Drug Toxicity
 Multiple Myeloma Antibodies  >3 publications with BCL3 and Multiple Myeloma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >30 publications with BCL3 and Blood
 Bone Antibodies  >10 publications with BCL3 and Bone
 Brain Antibodies  >8 publications with BCL3 and Brain
 Liver Antibodies  >7 publications with BCL3 and Liver
 Kidney Antibodies  >6 publications with BCL3 and Kidney
 Skin Antibodies  >5 publications with BCL3 and Skin
 Spleen Antibodies  >4 publications with BCL3 and Spleen
 Lymph Node Antibodies  >4 publications with BCL3 and Lymph Node
 Placenta Antibodies  >3 publications with BCL3 and Placenta
 Thyroid Antibodies  >3 publications with BCL3 and Thyroid
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