NP_079204.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,119 Da
NCBI Official Full Name
CST complex subunit STN1
NCBI Official Synonym Full Names
oligonucleotide/oligosaccharide-binding fold containing 1
NCBI Official Synonym Symbols
STN1; AAF44; AAF-44; RPA-32; bA541N10.2 [Similar Products]
NCBI Protein Information
CST complex subunit STN1; alpha accessory factor 44; suppressor of cdc thirteen homolog; replication protein A 32 kDa subunit; oligonucleotide/oligosaccharide-binding fold-containing protein 1
UniProt Protein Name
CST complex subunit STN1
UniProt Synonym Protein Names
Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog
UniProt Synonym Gene Names
UniProt Entry Name
STN1_HUMAN
NCBI Summary for OBFC1
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
UniProt Comments for OBFC1
OBFC1: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Belongs to the STN1 family.
Chromosomal Location of Human Ortholog: 10q24.33
Cellular Component: nucleoplasm; intermediate filament cytoskeleton; nuclear chromosome, telomeric region; intracellular membrane-bound organelle; nucleolus; nucleus
Molecular Function: protein binding; single-stranded telomeric DNA binding; single-stranded DNA binding
Biological Process: telomere maintenance; positive regulation of DNA replication
Research Articles on OBFC1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with OBFC1 elisa kit
Diseases associated with OBFC1 elisa kit
Organs/Tissues associated with OBFC1 elisa kit
|